Güncel Gönderiler: Moleküler Biyoloji ve Genetik-Makale Koleksiyonu
Toplam kayıt 75, listelenen: 41-60
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Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
Molecular cloning and biochemical characterization of a Tau class glutathione S-transferase from Pinus brutia Ten
(Springer Heidelberg, 2020)Key message A new Tau class GST gene was cloned from Pinus brutia Ten. cDNA sequence was analysed for conserved sequences. Substrate specificity, optimum pH, and temperature values of the recombinant PbGST Tau enzyme were ... -
Evaluation of Azadirachtin on Arthrospira plantensis Gomont growth parameters and antioxidant enzymes
(EDP Sciences S A, 2020)To understand the effects of contamination of insecticides onphototrophs, and to determine the responses of these organisms against these chemicals are extremely important in understanding how the ecosystem is affected. ... -
Synthesis, characterization, and their some chemical and biological properties of PVA/PAA/nPS hydrogel nanocomposites: Hydrogel and wound dressing
(Sage Publications, 2020)The nanocomposite hydrogels were prepared by dispersing of the nanopomegranate seed particles into poly(vinyl alcohol)/poly(acrylic acid) blend matrix in an aqueous medium by the solvent casting method. These hydrogels ... -
TNF-alpha induces URG-4/URGCP gene expression in hepatoma cells through starvation dependent manner
(Springer/Plenum Publishers, 2020)URG-4/URGCP is a gene that may be associated with the onset of tumorigenesis and cell cycle regulation. In the literature, there is no study about inflammatory cytokine-mediated URG-4/URGCP regulation. In this study, the ... -
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
(Springer Wien, 2020)Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ... -
The effects on antioxidant enzymes of PMMA/hydroxyapatite nanocomposites/composites
(Elsevier Sci Inc, 2020)In this study, polymer-ceramic nanocomposites and/or composites were prepared by solution removal method using poly(methylmethacrylat) (PMMA) and nano-hydroxyapatite (nHA). They were characterized using X-ray diffraction ... -
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation
(Academic Press Inc Elsevier Science, 2020)In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well ... -
Carbonic anhydrase III is a new target of HIF1 alpha in prostate cancer model
(Elsevier, 2020)Carbonic Anhydrase III (CAIII) belongs to a member of the alpha Carbonic Anhydrase (CA) family. Although some CA members are strongly up-regulated by HIF1-alpha, it is not known about the transcriptional regulation of CAIII ... -
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ... -
Synthesis, characterization and some biological properties of Pva/Pvp/Pn hydrogel nanocomposites: Antibacterial and biocompatibility
(Sciendo, 2019)In this study, it was aimed to synthesize hydrogel based antibacterial, biocompatible and non-toxic wound dressing materials by solvent removal method usingpoly(vinylalcohol) (PVA), poly(vinylpyrolidone) (PVP) and nano ... -
TGF-beta downregulates CAIII expression via MAPK and PI3K signaling pathways in colon carcinoma and osteosarcoma cells
(Inst Bioloska Istrazivanja Sinisa Stankovic, 2019)Identification of cancer-associated genes is critical for developing effective treatments of colorectal cancer (CRC). A limited number of studies have examined the mechanisms and genes underlying CRC. Abnormal transforming ... -
Synthesis, characterization and biological properties of intercalated kaolinite nanoclays: intercalation and biocompatibility
(De Gruyter Poland Sp Zoo, 2019)The aims of the present study were to synthesize the intercalated kaolinite samples with dimethylsulfoxide (DMSO), glutamic acid (GA), succinimide (SIM), cetylpyridiniumchloride (CPC), and hexadecyltrimethylammoniumchloride ... -
A simple way to synthesize tartaric acid, ascorbic acid and their mixture coated superparamagnetic iron oxide nanoparticles with high saturation magnetisation and high stability against oxidation: Characterizations and their biocompatibility studies
(Elsevier Science BV, 2019)A simple way to synthesise biocompatible superparamagnetic iron oxide nanoparticles coated with ascorbic acid, tartaric acid and a mixture of ascorbic acid and tartaric acid is proposed. The iron oxide nanoparticles were ... -
Phenolic content, antioxidant activities and stimulatory roles of citrus fruits on some lactic acid bacteria
(Inst Bioloska Istrazivanja Sinisa Stankovic, 2015)In this study, phenolic compounds and antioxidant activities in citrus fruits and their peels were determined, and their stimulatory roles on some lactic acid bacteria were investigated. Phenolic compounds in citrus fruits ... -
Synthesis, spectroscopic characterization, and antimicrobial activities of Ni(II) and Fe(II) complexes with N -(2-hydroxyethyl)-5-nitrosalicylaldimine
(Taylor & Francis Ltd, 2013)Metal complexes [Ni(HL1)(2)H2O] (1) and [Fe(HL1)(2)] (2), where HL1 is the tridentate Schiff base N-(2-hydroxyethyl)-5-nitrosalicylaldimine, were synthesized and characterized by spectroscopic methods. The crystal structures ... -
In silico and expression analysis of urg-4/urgcp gene in different cancer cells
(Nobel Science and Research Center, 2015)Upregulated gene 4 (URG-4/URGCP) located in chromosome 7 (7p13), was originally suggested as one of the HBxAg upregulated genes in hepatoma cells and implicated in tumorogenesis process in different cells. In this study ... -
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, beta-lactamase enzyme inhibition studies
(Taylor & Francis Ltd, 2016)The aims of this study were to examine the antiproliferation of Humulus lupulus extracts on human hepatoma carcinoma (Hep3B) and human colon carcinoma (HT-29) cell lines along with enzyme inhibitory effects of the crude ... -
In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and beta-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice
(Taylor & Francis Ltd, 2016)Increases in the risk of infections and malignancy due to immune suppressive therapies of inflammatory bowel diseases (IBDs) have led the researchers to focus on more nontoxic and acceptable natural products like curcumin. ... -
Synthesis, characterization, antibacterial, and antifungal activities of one-dimensional O-H center dot center dot center dot O hydrogen-bonded Cu(II) and Ni(II) complexes
(Taylor & Francis Inc, 2016)Two Schiff base complexes, [Cu(HL)(2)], 1 and [Ni(HL)(2)], 2 [H2L = 2-((E)-(2-hydroxyethylimino)methyl)-1-naptaphenol] have been synthesized and characterized by elemental analysis, H-1 NMR, C-13 NMR, IR spectroscopy, and ...
