Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Ballistic performance of multi-layered armor combinations under 7.62 x 51 mm FMJ bullet impact
(Walter de Gruyter GMBH, 2026) Özer, Mehmet; Ferikel, Kaan; Balıkoğlu, Fatih; Demircioğlu, Tayfur Kerem; Yılmazçoban, İbrahim Kutay; Çivi, Can
This work performed a nonlinear numerical analysis of Armox 500T and Hardox 450 armor steels, Kevlar 29/epoxy laminate, and aluminum honeycomb materials under ballistic conditions, validating the results via experimental data. The ballistic performance of 20 distinct armor configurations was investigated, including monolithic steel, steel-composite, and steel-composite-honeycomb panels produced by various material arrangements. Ballistics tests were conducted using 7.62 x 51 mm full metal jacket bullets with a muzzle velocity of 838 +/- 15 m s-1 under the NIJ 0108.01 III protection level standard. The effect of Kevlar29/epoxy layer thickness in multi-layered panels was examined extensively. The results showed that the ballistic performance of the composite armors was significantly improved due to the combination of monolithic steel plates with Kevlar 29/epoxy and aluminum honeycomb layers. Steel-Kevlar 29/epoxy and steel-Kevlar 29/epoxy-honeycomb multi-layered plates provide identical ballistic protection to monolithic steel counterparts while being 51 wt.% and 57 wt.% lighter than monolithic steel armor. Comprehensive finite element simulations of the ballistic impact events were conducted to elucidate the phenomena of defeat and penetration with greater precision.
Electrical cardiometry as a novel tool for assessing systemic vascular resistance and cardiac function in obstructive sleep apnea
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Yıldırım, Seda Elçim; Sarıoğlu, Nurhan; Çolak, Mustafa; Tanrıöğen, İbrahim; Yıldırım, Tarık; Kırış, Tuncay; Avcı, Eyüp
Background: Obstructive sleep apnea syndrome (OSAS) is associated with sympathetic overactivity, intermittent hypoxia, and increased vascular resistance, leading to cardiovascular morbidity. Electrical cardiometry (EC) is a novel, non-invasive technology that continuously measures hemodynamic parameters such as systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), cardiac output (CO), and cardiac index (CI). The aim of this study was to compare SVR and SVRI values, measured by EC, between patients with OSAS and age- and sex-matched healthy controls. Methods: In this retrospective case–control study, 70 participants were enrolled, including 33 patients with polysomnography-confirmed OSAS and 37 healthy controls matched for age and sex. All participants underwent standard EC measurement (ICON® Cardiotronics, Osypka Medical, GmbH, Berlin, Germany) under resting, supine conditions. Hemodynamic parameters such as SVR, SVRI, and CI were compared between groups. Results: EC revealed significantly higher SVR (1498.7 ± 335.6 vs. 1260.1 ± 251.5 dyn·s·cm−5, p = 0.013) and SVRI (2969.4 ± 749.1 vs. 2347.4 ± 481.0 dyn·s·cm−5·m2, p < 0.001) in patients with OSAS compared with controls, while CI was significantly lower in the OSAS group (2.6 ± 0.5 vs. 3.2 ± 0.8 L/min/m2, p < 0.001), indicating increased vascular load and reduced cardiac performance. Conclusions: This study is the first to apply EC in OSAS. EC-derived parameters, particularly SVRI and CI, effectively differentiated OSAS patients from healthy subjects, reflecting increased vascular afterload and reduced cardiac performance. These findings suggest that EC is a feasible, non-invasive tool for assessing hemodynamic alterations in OSAS and may have potential for bedside monitoring and future risk stratification studies.
Psychometric properties of the Turkish version of the pediatric-friendly care assessment scale in the emergency department
(Elsevier, 2026) Kösem, Dilek Demir; Bektaş, Murat; Ergün, Sibel; Kaynak, Serap
Aim: This study aimed to adapt and evaluate the validity and reliability of the Pediatric-Friendly Care Assessment Scale in the Emergency Department, which assesses nurses' perceptions of the importance of pediatric-friendly care. Method: This methodological study was conducted with 301 nurses working in pediatric emergency departments. Linguistic adaptation was performed using forward-backward translation, and content validity was evaluated using the Davis technique. Construct validity was assessed through confirmatory factor analysis (CFA). Reliability was examined using Cronbach's alpha, split-half method, and Spearman-Brown and Guttman coefficients. Additionally, item-total correlations and known-group comparisons were conducted. Results: The mean age of the participants was 39.35 +/- 5.80 years, and 82.1% were female. The scale-level content validity index was found to be 0.98 based on expert evaluations. CFA results showed that the model fit was acceptable (CMIN/DF = 2.485, RMSEA = 0.070, CFI = 0.88, IFI = 0.88, GFI = 0.83, NFI = 0.82, TLI = 0.86). The Cronbach's alpha coefficient of the total scale was 0.93, and the alpha values for the sub-dimensions ranged from 0.60 to 0.84. Item-total scale score correlations were between 0.25 and 0.79. Conclusion: The findings indicate that the Turkish form of the scale is a valid and reliable tool for evaluating nurses' perceptions of the importance of pediatric-friendly care in pediatric emergency departments. Implications for practice The scale can be used to evaluate pediatric-friendly care practices in pediatric emergency departments and to guide training and quality improvement initiatives in this field. (c) 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Inflammatory cytokine IL-6 regulates ADAMTS14 expression through MAPK and PI3K signaling in colorectal cancer
(Wiley, 2026) Hacıoğlu, Nelin; Ondul, Rümeysa Nur Vapur; Ismael, Ghufran Haqi; Köçkar, Feray
Extracellular matrix (ECM) remodeling is a critical component of colorectal cancer (CRC) progression and tumor microenvironment organization. Members of the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) metalloproteinase family are known regulators of ECM structure; however, the transcriptional regulation of ADAMTS14 and its potential role in inflammation-associated ECM remodeling remain poorly understood. In this study, we investigated whether inflammatory signaling regulates ADAMTS14 expression and explored its association with ECM organization in CRC. Interleukin-6 (IL-6) stimulation significantly increased ADAMTS14 expression at both mRNA and protein levels in CRC cells. Promoter deletion analyses identified a critical IL-6-responsive region between -145 and -43 bp upstream of the transcription start site, suggesting transcriptional responsiveness of ADAMTS14 to inflammatory signaling. Inhibition experiments demonstrated that Extracellular Signal-Regulated Kinase, c-Jun N-terminal Kinase, Phosphatidylinositol 3-Kinase, and Nuclear Factor Kappa B pathways were associated with IL-6-induced ADAMTS14 expression. Transcriptomic analyses of The Cancer Genome Atlas CRC datasets revealed that ADAMTS14 expression is elevated in tumors and is associated with inflammatory signaling, stromal activation, fibroblast-related gene expression, and ECM organization pathways. Functional enrichment analyses indicated that ADAMTS14-correlated genes are primarily involved in ECM organization, collagen fibril organization, and connective tissue development. Together, these findings identify ADAMTS14 as an inflammation-responsive ECM-associated metalloproteinase and suggest that IL-6 signaling may be associated with ECM-related transcriptional programs through regulation of ADAMTS14 expression. Our findings further suggest that ADAMTS14 expression may be associated with inflammatory and stromal-related transcriptional programs in CRC.
An evaluation of breast augmentation: accuracy, utility, and accessibility of knowledge for patient education and consultation with artificial intelligence
(Springer, 2026) Işıktekin, Emrah; Kırış, Yusuf Furkan; Kılıç, Salih; Gözel, Betül
BackgroundThe purpose of this study is to compare the answers of the 12 most frequently asked questions regarding breast augmentation surgery on both Google Gemini and ChatGPT-4.5. Our research highlights the growing importance and differential performance of artificial intelligence models in informing patients before surgery.MethodsThe 12 most asked questions about breast augmentation, based on user engagement metrics, were obtained from the Realself website. These twelve questions were investigated on both Google Gemini and ChatGPT-4.5. Information received from both platforms was analyzed and evaluated by ten plastic surgeons with European Board of Plastic Reconstructive and Aesthetic Surgery (EBOPRAS) certification. The surgeons, who reached a consensus on the application of the Global Quality Score (GQS) scale prior to evaluation, were blinded to the source of the answers. The GQS scale was used for the evaluation.ResultsThe average results obtained were compared with each other. While the average of Google Gemini responses was calculated at 2.842, the average of ChatGPT-4.5 responses was calculated at 3.867. For this calculation, the Wilcoxon signed-rank test was used. It was found that the ChatGPT-4.5 responses were statistically superior to Google Gemini according to the Global Quality Score (GQS) (p = 0.003).ConclusionWhile there is emerging research on AI in plastic surgery, studies specifically comparing ChatGPT and Gemini for breast augmentation patient education using a blinded evaluation by board-certified surgeons remain limited. We suggest that AI-powered chatbots offer significant advantages for patient education but should be used cautiously. While ethical concerns persist, this study underscores the practicality of ChatGPT in informing patients about plastic surgery procedures, emphasizing the need for careful usage and collaboration to optimize benefits while minimizing risks.Level of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
