Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The path to effective resource management: Exploring the impact of eco-friendly innovations, clean energy transition, economic development and trade in G-7 countries
(John Wiley and Sons Inc, 2026) Biçen, Ömer Faruk; Çoban, Mustafa Necati
As one of the international economic organizations, the G-7 countries are composed of the world's leading industrialized countries. In addition, the role of the G-7 countries in global warming is another issue that is constantly debated. Concerns have been raised about these very wealthy nations' capacity to manage their resources sustainably. Examining the factors that contribute to efficient resource management in these nations has grown in significance. The goal of this research is to look at how eco-friendly innovations, clean energy transition, economic development, and trade affect effective resource management in the G-7 nations. The material footprint is used as a gauge for efficient resource management. The Method of Moments Quantile Regression (MMQR) approach, which is a novel method, was used in this research to examine the G-7 nations' yearly data for the years 1990–2019. Eco-friendly technologies lower the material footprint in the G-7 nations, according to MMQR findings. Results are statistically significant for the majority of quantile levels (0.1–0.7). Clean energy transition also reduces the material footprint of the G-7 countries, with statistically significant results at all quantile levels. Economic development increases the material footprints of G-7 countries; findings are statistically significant at all quantile levels. The material footprint is consequently increased by trade, and the results are statistically significant at various quantile levels (0.5–0.9). Additionally, the research tests robustness using other panel estimators and achieves similar findings. Lastly, the paper offers policy suggestions for G-7 nations' efficient resource management.
Nanoborate based decontamination of poultry carcasses
(John Wiley and Sons Inc, 2026) Tavşanlı, Hakan; Beyaz, Seda; Gül, Gülşah Çelik
Despite the implementation of strict biosecurity and food safety systems in broiler production, poultry products continue to be a significant source of foodborne pathogens. Traditional decontaminants, including chlorine dioxide (ClO2), have shown limited effectiveness in completely reducing this risk. We evaluated the antimicrobial activity of novel nanoborate solutions prepared from polyborates using a nanotechnological approach compared with chlorine dioxide. The optimized nanoborate formulation demonstrated superior antimicrobial activity by achieving approximately 105 CFU/mL bactericidal activity at 1 min and 106 CFU/mL at 30 min, approaching TS EN 1656 standards. Remarkable reductions in the concentrations of TAMB, Pseudomonas spp., lactic acid bacteria, and Enterococcus spp. were observed in poultry carcasses treated with the nanoborate solution by day 12 (p < 0.05). On Day 12, carcasses treated with nanoborate exhibited reductions of 2.5 log CFU/carcass in TAMB, 1.5 log CFU/carcass in Pseudomonas spp., 2.96 log CFU/carcass in lactic acid bacteria on MRS agar, 2.85 log CFU/carcass on M17 agar, and 4.29 log CFU/carcass on KE agar (p < 0.05). Poultry carcasses treated with nanoborate displayed enhanced microbiological quality and exhibited an approximate 50% increase in shelf life relative to the control group. Results from sensory examination demonstrated that nanoborate-treated carcasses preserved acceptable quality on Day 12. Elemental analysis verified the existence of very trace amounts of boron residue. Upon assessing the application of a nanoborate solution regarding public health, it could potentially be an appropriate alternative decontaminant for poultry carcass disinfection.
Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma
(Springer Heidelberg, 2026) Hacıoğlu, Nelin; Dülger, Aylin Türkoğlu; Koç, Sevin Avşar; Tokay, Esra; Alper, Meltem; Koçkar, Feray
Background: Hepatocellular carcinoma (HCC) develops in a chronically hypoxic microenvironment; however, the contribution of hypoxia-regulated long non-coding RNAs (lncRNAs) remains poorly defined. Aim: We aimed to identify
MIR100HG as a hypoxia-responsive regulator in hepatocellular carcinoma (HCC) and to define its transcriptional control
by hypoxia-inducible factor 1 alpha. Methods: Basal MIR100HG expression was analyzed in four hepatocellular carcinoma
cell lines (Hep3B, Huh-7, SNU-398, and SNU-475) and non-tumorigenic Clone-9 hepatocytes. Hypoxia was induced by
cobalt (II) chloride. Proliferation, migration, and clonogenicity were evaluated using functional assays. Promoter analysis,
electrophoretic mobility shift assay, chromatin immunoprecipitation quantitative polymerase chain reaction, and 5′-deletion luciferase assays were used to map the hypoxia response elements. Transcriptomic profiling was performed using
RNA sequencing, followed by gene set enrichment analysis. Gain- and loss-of-function experiments validated the downstream effects. Results: MIR100HG expression was highest in Hep3B cells and was significantly induced under hypoxia
in all hepatic models, indicating a conserved, oxygen-sensitive response. Hypoxia suppressed proliferation, migration, and
clonogenicity, with the strongest inhibition observed in non-tumorigenic hepatocytes under hypoxic conditions. Functional
hypoxia response elements were identified within the −815/+231 promoter region, demonstrating direct transcriptional
activation by hypoxia-inducible factor 1 alpha. Transcriptomic analyses revealed the enrichment of hypoxia signaling, oxidative stress, proteasome activity, RNA metabolism, autophagy, and ferroptosis pathways. While hypoxia induced broad
transcriptional reprogramming, MIR100HG modulated the expression of selected hypoxia-responsive genes, including the
PAGE1 and CTAG2, as demonstrated under hypoxic conditions by RNA-seq and functional perturbation experiments.
Conclusions: MIR100HG is a hypoxia-inducible factor 1 alpha-driven long non-coding RNA associated with hypoxiaresponsive transcriptional programs in hepatocellular carcinoma and represents a potential biomarker and therapeutic
target.
Anti-mycobacterial, cytotoxic effects of penicillium mallochii ethanol extract, and quantitative detection of its extrolites by lc-q-tof-ms/ms
(Springer, 2026) Aşkun, Tülin; Cantürk, Zerrin; Güner, Pınar
Tuberculosis and cancer are the most critical global health problems of our time, and the diseases that cause the most deaths globally. This investigation focused on Penicillium mallochii, a key component of our fungus collection, which is registered in GenBank under the number MG591446. In this study, the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of P. mallochii ethanol extract (EE) against Mycobacterium species, as well as their cytotoxic activities on cell lines, were investigated. For this purpose, the anti-mycobacterial activity of P. mallochii EE extract was tested against all tuberculosis (TB) strains, including avirulent Mycobacterium tuberculosis H37Ra (MT-H37Ra) and virulent Mycobacterium tuberculosis H37Rv (MT-H37Rv), and six clinical strains (MT-1 to MT-6). It has also been investigated to explore its anticancer activity on HL-60, K562, and A549 cancer cell lines. Additionally, Liquid chromatography-quadrupole time-of-flight tandem mass spectrometry analysis (LC-Q-TOF-MS/MS) enabled the identification of a total of four compounds in the EE, including harmane, kojic acid, simvastatin, and lovastatin. We have provided information about its extrolite content and antituberculosis and cytotoxic effects. P. mallochii is a potential microorganism for future medical drug studies due to its promising antituberculosis activity, cytotoxic effects, and valuable extrolites.
Relations between the development of false belief and scientific reasoning in Turkish preschoolers
(John Wiley and Sons Ltd, 2026) Saçkes, Mesut; Işıtan, Sonnur; Özgül, Sinem Güçhan; Avci, Kerem; Trundle, Kathy Cabe; Sobel, David M.
Previous studies have shown relations between the emergence of theory of mind capacities and children's scientific reasoning in Western samples. Previous studies have also shown that Turkish preschoolers have a different trajectory for theory of mind development than their Western counterparts. This study extends these previous findings to examine relations between the emergence of false belief understanding and different facets of scientific reasoning in Turkish preschoolers (aged 3 to 5), particularly focused on the difference between understanding others' false belief and one's own representational change. Study 1 revealed a positive relation between preschoolers' capacity to infer another's false belief and their experimentation skills when unconfounded interventions were presented to them. This finding did not extend to children's ability to report their own representational change. Study 2, however, showed that this relation with false belief did not extend to a case in which children had to design their own interventions to implement the control of variables strategy. The results suggest links between children's understanding of false belief and their nascent scientific reasoning among Turkish preschoolers.
