Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Investigation of the deformation and thrust forces generated during the drilling of GFRP composites
(Yildiz Technical University, 2026) Nehri, Yunus Emre; Şener, Mert; Kirzuk, Sıla Betül; Çetiner, Sudem; Dinçer, Osman Talha; Oral, Ali
Glass fiber-reinforced polymer (GFRP) composites are widely used in industry due to their
advantageous properties, such as a high strength-to-weight ratio. However, during the preparatory processes for bolted or riveted joints, drilling operations often lead to delamination
damage, which adversely affects the mechanical performance and reliability of these materials.
In this study, the effects of different cutting speeds and feeds on thrust force and delamination
damage during the drilling of GFRP composites were investigated. The maximum thrust forces generated during the hole drilling process were measured, and post-drilling deformations
were examined. Mathematical models were developed using the response surface method
(RSM) to predict thrust force and delamination under various cutting conditions determined
by the selected drill geometry. The results of the analysis of variance (ANOVA) showed that
the developed models were statistically significant with a confidence level of over 90%. It was
found that feed is the dominant parameter influencing thrust force, whereas cutting speed
plays a primary role in determining the extent of delamination. The results provide valuable
insights for establishing optimum cutting conditions aimed at minimizing drilling damage in
GFRP composite machining.
9.sınıf fizik ders kitabı etkinliklerinin 2024 Türkiye yüzyılı maarif modeli fizik öğretim programına uygunluğunun incelenmesi
(Balıkesir Üniversitesi, 2026) Ad, Vahide Nilay Kırtak; Küçüközer, Hatice Asuman; Çoramık, Mustafa; Arslanboğa, Sevecen; Çiçek, Gülşen
Bu çalışma, 2024 yılında güncellenen Türkiye Yüzyılı Maarif Modeli (TYMM)
doğrultusunda hazırlanan 9. sınıf fizik dersi öğretim programında bulunan alan ve
kavramsal beceriler çerçevesinde fizik ders kitabındaki etkinliklerin uygunluğunu
değerlendirmeyi amaçlamaktadır. Araştırma, nitel araştırma desenlerinden doküman
incelemesi yöntemi kullanılarak yürütülmüştür. Veri kaynaklarını 2024 yılına ait 9. sınıf
fizik dersi öğretim programı ile aynı yıla ait ders kitabı oluşturmaktadır. Ders kitabında
yer alan tüm etkinlikler, öğretim programında tanımlanan öğrenme çıktıları, süreç
bileşenleri ve beceriler dikkate alınarak geliştirilen “Etkinlik–Beceri Eşleştirme Formu”
aracılığıyla analiz edilmiştir. Etkinlikler “uygun”, “kısmen uygun” ve “uygun değil”
kategorileri altında sınıflandırılmıştır. Kodlayıcılar arası uyum katsayısı 0,90 olarak
hesaplanmıştır. Bulgular, ders kitabındaki etkinliklerin kısmen öğretim programının
hedeflediği becerilerle örtüştüğünü, özellikle 1. ve 2. ünitelerde yer alan bazı etkinliklerin
öğrencilerin tümevarımsal akıl yürütme, sınıflandırma ve sorgulama gibi becerilerini
geliştirmede yetersiz kaldığını göstermektedir. Buna karşılık, 3. ve 4. ünitelerdeki
etkinliklerin öğretim programına daha iyi uyum sağladığı değerlendirilmiştir. Ayrıca,
bazı etkinliklerde öğrencilere sunulan hazır tanımlar ve kontrol noktaları, programın
beceri temelli yaklaşımıyla çelişmektedir. Sonuç olarak, ders kitabında yer alan
etkinliklerin bazılarının TYMM öğretim programının felsefesi doğrultusunda gözden
geçirilmesi ve yeniden yapılandırılması önerilmektedir.
Comparative evaluation of the anti-proliferative, apoptotic, and migratory effects of aronia melanocarpa fruit extract on breast cancer cells and healthy endothelial cells
(Akif Enes Arıkan, 2026) Tosun, Sinem Gültekin; Avcıkurt, Ayla Solmaz
Purpose: Aronia melanocarpa fruit, known for its antioxidant and cytotoxic properties, is recognized as a potential natural agent in cancer research. This investigation evaluated the in vitro effects of aronia fruit extract on cytotoxicity, cell migration, and the expression of apoptotic genes in MDA-MB-231 breast cancer cells and HUVEC healthy endothelial cells were examined. Methods: Cytotoxicity analyses were performed using the MTT assay, cell migration was assessed by scratch assay, and apoptotic gene expression was evaluated by RT-qPCR in MDA-MB-231 and HUVEC cells. Experiments were carried out in triplicate. For statistical evaluation, all analyses were performed using ANOVA, and differences with a p value of less than 0.05 were considered significant. Results: The cytotoxicity experiments demonstrated that the extract reduced the viability of MDA-MB-231 cells in a manner dependent on both exposure time and concentration, while in contrast, HUVEC cells exhibited an increase in viability after 24 and 48 hours of treatment. The IC₅₀ value was 148.92 µg/mL. cratch assays showed that the extract suppressed migration in MDA-MB-231 cells with no effect on HUVEC cells. RT-qPCR revealed increased Bcl-xL and decreased Bak, Caspase-3, and Caspase-8 in HUVEC cells, whereas MDA-MB-231 cells exhibited reduced Bcl-xL and elevated Bak, Caspase-3, and Caspase-8. Conclusion: These findings indicate that aronia fruit extract exhibits selective pro-apoptotic and cytotoxic effects in breast cancer cells while maintaining a safe profile in healthy cells. Further studies are required to elucidate molecular mechanisms related to apoptosis and evaluate the preclinical and clinical potential of aronia fruit extract.
Challenges and experience factors related to anatomical variations in invasive procedures in the emergency department of a university hospital
(Effect Publishing Agency ( EPA ), 2026) Kıyak, Ramazan; Taşkın, Gökhan
Anatomical variations may complicate invasive procedures in the emergency department (ED) and reduce procedural success. This study aimed to evaluate the impact of anatomical variations on the success of invasive procedures and to examine the effects of medical staff experience, professional role, and imaging device use. This prospective observational study was conducted between January and September 2025 in the ED of a university hospital. A total of 96 adult patients with identified anatomical variations during invasive procedures were included. Demographic data, procedure type, medical staff characteristics, imaging device use, and procedural outcomes were recorded. Of the patients, 34.4% were female, and the median age was significantly higher in males than in females (p=0.019). A significant positive correlation was observed between years of professional experience and procedural success (r=0.561, p<0.001). Procedural success was significantly higher when anatomical variations were known before the intervention (61.9% vs. 36.0%, p=0.033). Success rates differed significantly according to professional role (p<0.001), with the highest rates observed among paramedics and emergency medical technicians. Although procedures performed with imaging device support showed higher success rates, this difference was not statistically significant (p=0.317). No significant association was found between procedure type and success rate (p=0.659). In ED invasive procedures, medical staff experience and prior awareness of anatomical variations are key determinants of procedural success. These findings are consistent with existing literature emphasizing the importance of experience and anatomical assessment in improving first-attempt success and patient safety in emergency care settings.
Aromatic amine migration from commonly used kitchen utensils marketed inTurkey: Detection and quantification using LC-MS/MS
(Taylor and Francis Ltd., 2026) Kıralan, Sündüz Sezer; Toptancı, İsra; Ramadan, Mohamed Fawzy
Primary aromatic amines (PAAs) are migrants, some of which are carcinogenic and classified by official organizations such as IARC Program. Consumers prefer kitchen utensils made of plastic, especially polyamides, for their ease of use and durability. Fifty-five samples of kitchen utensils were collected by retailers in Turkey. They were made of polyamide (40 samples), polypropylene (5 samples), polytetrafluoroethylene (5 samples), polyethylene (4 samples) and polystyrene (1 sample). Twenty targeted PAAs were analyzed in migration extracts using LC–MS/MS. Six PAAs-aniline (ANL), 4,4′-methylenedianiline (4,4′-MDA), 2,6-toluenediamine (2,6-TDA), 2,4-toluenediamine (2,4-TDA), 3,3′-dimethylbenzidine (3,3′-DMB), and o-toluidine (o-T) were detected in at least one of the 55 samples. ANL was the predominant PAAs in 20 samples below and above its limit of quantification (LOQ) values. The serving spoon (SS3 coded sample) had the highest aniline concentration at 0.057 mg/kg, followed by the crepe spatula (CS3) at 0.038 mg/kg. 4,4′-MDA and 3,3ˈ-DMB were detected below their LOQ values in four and only one of the samples. After the third migration test, no PAAs were detected in any sample. The detected PAA concentrations were low, suggesting a limited potential health risk for consumers under the tested migration conditions, although the presence of PAA highlights the importance of continued monitoring.
