Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Comparative evaluation of the anti-proliferative, apoptotic, and migratory effects of aronia melanocarpa fruit extract on breast cancer cells and healthy endothelial cells
(Akif Enes Arıkan, 2026) Tosun, Sinem Gültekin; Avcıkurt, Ayla Solmaz
Purpose: Aronia melanocarpa fruit, known for its antioxidant and cytotoxic properties, is recognized as a potential natural agent in cancer research. This investigation evaluated the in vitro effects of aronia fruit extract on cytotoxicity, cell migration, and the expression of apoptotic genes in MDA-MB-231 breast cancer cells and HUVEC healthy endothelial cells were examined. Methods: Cytotoxicity analyses were performed using the MTT assay, cell migration was assessed by scratch assay, and apoptotic gene expression was evaluated by RT-qPCR in MDA-MB-231 and HUVEC cells. Experiments were carried out in triplicate. For statistical evaluation, all analyses were performed using ANOVA, and differences with a p value of less than 0.05 were considered significant. Results: The cytotoxicity experiments demonstrated that the extract reduced the viability of MDA-MB-231 cells in a manner dependent on both exposure time and concentration, while in contrast, HUVEC cells exhibited an increase in viability after 24 and 48 hours of treatment. The IC₅₀ value was 148.92 µg/mL. cratch assays showed that the extract suppressed migration in MDA-MB-231 cells with no effect on HUVEC cells. RT-qPCR revealed increased Bcl-xL and decreased Bak, Caspase-3, and Caspase-8 in HUVEC cells, whereas MDA-MB-231 cells exhibited reduced Bcl-xL and elevated Bak, Caspase-3, and Caspase-8. Conclusion: These findings indicate that aronia fruit extract exhibits selective pro-apoptotic and cytotoxic effects in breast cancer cells while maintaining a safe profile in healthy cells. Further studies are required to elucidate molecular mechanisms related to apoptosis and evaluate the preclinical and clinical potential of aronia fruit extract.
Challenges and experience factors related to anatomical variations in invasive procedures in the emergency department of a university hospital
(Effect Publishing Agency ( EPA ), 2026) Kıyak, Ramazan; Taşkın, Gökhan
Anatomical variations may complicate invasive procedures in the emergency department (ED) and reduce procedural success. This study aimed to evaluate the impact of anatomical variations on the success of invasive procedures and to examine the effects of medical staff experience, professional role, and imaging device use. This prospective observational study was conducted between January and September 2025 in the ED of a university hospital. A total of 96 adult patients with identified anatomical variations during invasive procedures were included. Demographic data, procedure type, medical staff characteristics, imaging device use, and procedural outcomes were recorded. Of the patients, 34.4% were female, and the median age was significantly higher in males than in females (p=0.019). A significant positive correlation was observed between years of professional experience and procedural success (r=0.561, p<0.001). Procedural success was significantly higher when anatomical variations were known before the intervention (61.9% vs. 36.0%, p=0.033). Success rates differed significantly according to professional role (p<0.001), with the highest rates observed among paramedics and emergency medical technicians. Although procedures performed with imaging device support showed higher success rates, this difference was not statistically significant (p=0.317). No significant association was found between procedure type and success rate (p=0.659). In ED invasive procedures, medical staff experience and prior awareness of anatomical variations are key determinants of procedural success. These findings are consistent with existing literature emphasizing the importance of experience and anatomical assessment in improving first-attempt success and patient safety in emergency care settings.
Aromatic amine migration from commonly used kitchen utensils marketed inTurkey: Detection and quantification using LC-MS/MS
(Taylor and Francis Ltd., 2026) Kıralan, Sündüz Sezer; Toptancı, İsra; Ramadan, Mohamed Fawzy
Primary aromatic amines (PAAs) are migrants, some of which are carcinogenic and classified by official organizations such as IARC Program. Consumers prefer kitchen utensils made of plastic, especially polyamides, for their ease of use and durability. Fifty-five samples of kitchen utensils were collected by retailers in Turkey. They were made of polyamide (40 samples), polypropylene (5 samples), polytetrafluoroethylene (5 samples), polyethylene (4 samples) and polystyrene (1 sample). Twenty targeted PAAs were analyzed in migration extracts using LC–MS/MS. Six PAAs-aniline (ANL), 4,4′-methylenedianiline (4,4′-MDA), 2,6-toluenediamine (2,6-TDA), 2,4-toluenediamine (2,4-TDA), 3,3′-dimethylbenzidine (3,3′-DMB), and o-toluidine (o-T) were detected in at least one of the 55 samples. ANL was the predominant PAAs in 20 samples below and above its limit of quantification (LOQ) values. The serving spoon (SS3 coded sample) had the highest aniline concentration at 0.057 mg/kg, followed by the crepe spatula (CS3) at 0.038 mg/kg. 4,4′-MDA and 3,3ˈ-DMB were detected below their LOQ values in four and only one of the samples. After the third migration test, no PAAs were detected in any sample. The detected PAA concentrations were low, suggesting a limited potential health risk for consumers under the tested migration conditions, although the presence of PAA highlights the importance of continued monitoring.
From private cars to micromobility: Network modeling and environmental assessment of short-distance trips in Izmir
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Öğütveren, Emre; Haldenbilen, Soner
Urban transportation systems face increasing sustainability challenges due to the dominance of private-car use, particularly for short-distance trips. This study investigates the potential of micromobility to replace private-car travel on short-distance journeys and evaluates the resulting impacts on urban transportation networks and environmental sustainability. The analysis focuses on the Bornova district of Izmir and is based on a face-to-face survey conducted with 502 private-vehicle users. Survey data were analyzed using descriptive statistics, chi-square tests and a binary logit regression model to identify factors influencing the willingness to adopt micromobility. Within the surveyed sample of private-car users, modal-shift rates were estimated as 35% for trips up to 5 km and 33% for trips between 5 and 10 km. These rates were applied to the private-car demand and distance matrices developed for the year 2030 within the scope of the Izmir Transportation Master Plan, resulting in a revised private-car demand matrix and a separate demand matrix representing potential micromobility users. Network assignments were performed in the PTV VISUM modeling environment. Assignment results demonstrate notable network-level changes following micromobility integration. The total length of road segments with micromobility traffic volumes exceeding a threshold of 10 veh/h was calculated at 292.5 km. Environmental impacts were evaluated using a life-cycle assessment (LCA) framework, revealing an approximate 5.5% reduction in total life-cycle CO2 emissions. Overall, the findings provide quantitative evidence supporting micromobility as an effective component of sustainable urban transport strategies and offer guidance for local governments in infrastructure planning and policy development.
Exogenous applied proline may enhance the tolerance of sweet sorghum (Sorghum bicolor (L.) Moench) under water deficit stress
(Universidad del Zulia, 2026) Taş, Timuçin; Babacan, Orkun; Işık, Yahya; Genç, Tülay Turgut; Güngör, Hüseyin
Drought is a major abiotic stress that threatens global food security by reducing crop yield and quality. Foliar application of osmoprotectants such as proline offers a promising means to mitigate drought-induced damage. This study examined the effects of exogenous proline (P0, P200, P400, and P600 mg.L-1), sorghum genotype, and their interaction on morphological, physiological, biochemical, forage quality, and microbial traits under different drought levels (I100, I75, I50, and I25). Proline application increased dry matter by over 100 % under medium to severe deficits and enhanced root dry weight by 90 % at 75 % water reduction. The strongest response occurred in chlorophyll content (SPAD), reflecting improved photosynthetic stability. Exogenous proline reduced leaf drying by 25 % and alleviated drought-related declines in forage quality, as evidenced by improvements in NDF, ADF, and ADL. It also boosted peroxidase activity more than superoxide dismutase and catalase, minimizing hydrogen peroxide (H₂O₂) toxicity and oxidative stress. Even under extreme drought (I25), proline maintained plant vigor and improved water-use efficiency by 25-40 % at the seedling stage. Compared with the control, leaf chlorophyll content (SPAD values) decreased by 13.91 %, 24.28 %, and 31.85 % under the I75, I50, and I25 treatments, respectively, suggesting that SPAD measurements at the seedling stage may serve as a practical and cost-effective indicator for identifying drought-tolerant sorghum genotypes.
