Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Inhibition of monoamine oxidase A (Mao-A) enzyme by some medicinal herbs
(İzzet Kara, 2026) Güngör, Nurten; Doğan, Serap; Alan, Ümran; Diken, Mehmet Emin; Bayhan, Hamza
Monoamine oxidase (MAO) is a flavin-containing enzyme responsible
for the metabolism and regulation of neurotransmitter amines and plays a role in
neuropsychiatric disorders such as depression and mania. In this study, the
inhibitory effects of different concentrations of solutions prepared using distilled
water, ethanol, ethyl acetate, petroleum ether, and mixed extracts of Hypericum
perforatum, Ginkgo biloba , Lavandula angustifolia, Zingiber officinale, Tilia
tomentosa., Cinnamomum aromaticum, Menthae piperita, Thymus cherlerioides,
Portulaca oleracea, Trachystemon orientalis, Allium sativum, Petroselinum
crispum, and Spinacia oleracea were investigated on monoamine oxidase obtained
from rat liver. It was determined that the best inhibitor plant extract for MAO,
which has a value of IC₅₀, was 0.071 mg/mL and with a ratio of inhibition of
70.15% ethanol extract of Hypericum perforatum. Following H. perforatum, the
best inhibition effects were observed with the ethanol extract of Spinacia oleracea
(IC₅₀ = 0.074 mg/mL), Ginkgo biloba (IC₅₀ = 0.075 mg/mL), Allium sativum (IC₅₀
= 0.080 mg/mL), and the distilled water extract of H. perforatum (IC₅₀ value of
0.081 mg/mL), respectively. The findings demonstrate that these species can inhibit
the enzyme, highlighting their potential as therapeutic agents for neurological
disorders.
In vivo developmental and antioxidant effects of some Salvia species on Drosophila melanogaster
(Balıkesir Üniversitesi, 2026) Karakuş, Hanife Didem; Doğan, Serap; Kardaş, Begümhan Yılmaz; Diken, Mehmet Emin
Medicinal plants have long served as valuable sources of therapeutic agents, primarily due to their antioxidant and antigenotoxic properties. Turkey, known for its rich biodiversity and diverse climatic conditions, hosts approximately 10000 plant species with nearly 400 possessing medicinal potential. Among these, species of the genus Salvia are particularly prominent, traditionally used to treat a wide range of ailments including gastrointestinal, respiratory, cardiovascular, renal and cognitive disorders. In this study, it is the first time that the developmental toxicity and in vivo antioxidant activities of aqueous methanolic, ethanolic and ethyl acetate extracts of S. candidissima subsp. candidissima subsp. candidissima, S. multicaulis, S. suffruticosa and S. syriaca were evaluated using Drosophila melanogaster (larvae, pupae and adult). Developmental toxicity was assessed by measuring percentage of puparation, eclosion and overall survival. In vivo antioxidant activity was determined using DPPH, ABTS and FRAP assays. The results indicated that none of the extracts of S. suffruticosa except the methanolic extract affected the puparation and survival rates (p>0.05), while other plant extracts negatively influenced the normal developmental processes. All extracts of S. suffruticosa demonstrated high in vivo antioxidant capacities (80 % activity) according to the ABTS test, while methanolic and ethanolic extracts of S. candidissima subsp. candidissima, S. multicaulis and S. syriaca showed high antioxidant activities according to DPPH test (>50-70 % activity). FRAP test also showed that the Trolox equivalent antioxidant capacities reported here for S. multicaulis (0.0025–0.0060 g TE/g) and S. suffruticosa (0.0049–0.0061 g TE/g) indicate strong antioxidant potential. To conclude the results of the in vivo antioxidant activity, it is demonstrated in this study that the studied plant extracts didn’t harm the physiological antioxidant system (balance) of the whole organism and the studied Salvia species have strong potential for the development of effective natural antioxidant supplements.
In the shadow of an invasive and harmful fish parasite, schyzocotyle (Bothriocephalus) acheilognathi: An updated ınvasion revision with first record and an assessment of its possible threats to host fishes and public health
(Prof. Dr. Mevlüt Akçura, 2026) Aydoğdu, Nurten
Schyzocotyle acheilognathi (formerly Bothriocephalus acheilognathi), the Asian fish tapeworm of Asian origin, infects a wide range of freshwater fishes, particularly Cyprinidae, and poses a potential threat to native and endemic species in Türkiye. This study documents the first global record of S. acheilognathi in the endemic freshwater fish Squalius pursakensis (Hankó, 1925), while also providing an updated overview of its invasion and potential risks to host fishes and public health. A total of 98 specimens of S. pursakensis were collected seasonally from Sarısu Stream (Eskişehir, Türkiye) between February and November 2023. Of these, six were infected, yielding 25 parasites. The overall prevalence and mean intensity were 6.12 % and 4.87, respectively. Infection parameters were further analyzed according to season, host size, and sex. Literature review indicated that S. acheilognathi currently parasitizes 28 freshwater fish species in Türkiye, though only 106 of 427 fish species have been studied ichthyo-helminthologically. This highlights significant gaps in knowledge and the limited scope of current surveys. Histopathological effects, ecological consequences, and potential public health risks of the parasite warrant attention, given its capacity to spread rapidly across freshwater ecosystems. By reporting a new host and locality record for S. acheilognathi, this study expands the known geographical and host distribution of the parasite. Furthermore, the findings emphasize the need for continuous monitoring, comprehensive parasitological surveys, and risk assessments to safeguard aquatic biodiversity and reduce possible threats to fish populations and human health.
Hibrit çalışma modelinde örgütsel adanmışlık: Kuşaklar arası ve cinsiyet temelli farklılıkların rol kuramı çerçevesinde değerlendirilmesi
(DİSK Birleşik Metal-İş, 2026) Gökçe, Çiğdem; Bolat, Oya İnci
Bu araştırma, hibrit çalışma modelinde istihdam edilen bireylerin örgütsel adanmışlık düzeylerinin kuşak ve cinsiyet değişkenleri bağlamında nasıl farklılaştığını Rol Kuramı çerçevesinde incelemeyi amaçlamaktadır. Türkiye'de hibrit çalışma modeliyle çalışan 400 katılımcıdan elde edilen veriler; İki Yönlü Varyans Analizi, Tukey HSD post-hoc testi ve hiyerarşik regresyon analizi ile incelenmiştir. Bulgular, örgütsel adanmışlık düzeyinin kuşaklar arasında istatistiksel olarak anlamlı biçimde farklılaştığını ortaya koymuştur. Post-hoc karşılaştırmalar, üç kuşak çiftinin de birbirinden anlamlı biçimde ayrıştığını göstermiş; Z Kuşağı en yüksek, Y Kuşağı orta düzey ve X Kuşağı en düşük adanmışlık ortalamasına sahip olmuştur. Cinsiyetin tek başına anlamlı bir ana etki oluşturmadığı belirlenmiş; ancak kuşak ve cinsiyet değişkenlerinin etkileşim etkisinin istatistiksel olarak anlamlı olduğu saptanmıştır. Ayrıva hiyerarşik regresyon analizi, cinsiyetin örgütsel adanmışlık üzerindeki etkisinin bağımsız bir grup farklılığı biçiminde değil, kuşak yapısıyla birlikte işleyen koşullu bir etki olarak ortaya çıktığını göstermiştir. Basit etkiler analizi, cinsiyet farkının yalnızca Y Kuşağında istatistiksel anlamlılığa ulaştığını; Z Kuşağında ise örüntünün tersine döndüğünü ve kadın çalışanların erkek çalışanlardan daha yüksek örgütsel adanmışlık sergilediğini ortaya koymuştur. Rol Kuramı çerçevesinde değerlendirilen bu bulgular, örgütsel adanmışlığın tekil demografik değişkenlerle değil, bu değişkenlerin kesişimsel yapısıyla şekillendiğini göstermekte; hibrit çalışma bağlamında demografik çeşitliliğin bütüncül ve kapsayıcı bir çerçeveden ele alınması gerektiğini ortaya koymaktadır.
Heavy metal levels (As, Cd, Hg, Pb, B) in well and tap water from Savaştepe, Balikesir (Türkiye): An ICP-MS based risk assessment
(Kırgızistan-Türkiye Manas Üniversitesi, 2026) Çelebi, Murat; Dikici, Selin
Heavy metal contamination is an increasing environmental and public health concern, especially in
regions where agricultural, domestic, and mining activities overlap. This study evaluated arsenic (As),
cadmium (Cd), mercury (Hg), lead (Pb), and boron (B) concentrations in well and tap water from the
Savaştepe district of Balıkesir, Türkiye. Twenty samples were analyzed using inductively coupled
plasma mass spectrometry (ICP-MS) following American Public Health Association and United States
Environmental Protection Agency protocols. Samples were digested with HNO₃/H₂O₂, stored at 4 °C,
and quantified using calibration curves between 10–500 ppb (R² ≥ 0.999). Detection and quantification
limits were determined using signal to noise ratios of 3 and 10, and values below LOQ were treated
using the LOQ/2 method. Clear spatial variation was observed, with well water exhibiting higher As,
Pb, and B levels than tap water. Mean concentrations were 2489.20 ± 3270.43 ppb (As), 13.99 ± 20.46
ppb (Cd), 0.0135 ppb (Hg), 504.01 ± 240.93 ppb (Pb), and 12083.32 ± 12913.85 ppb (B). Several well
samples exceeded WHO and USEPA limits, particularly for As and Pb, indicating contamination
likely linked to geological and mining activities. These findings emphasize the need for regular
monitoring and mitigation in Savaştepe.
