Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Aromatic amine migration from commonly used kitchen utensils marketed inTurkey: Detection and quantification using LC-MS/MS
(Taylor and Francis Ltd., 2026) Kıralan, Sündüz Sezer; Toptancı, İsra; Ramadan, Mohamed Fawzy
Primary aromatic amines (PAAs) are migrants, some of which are carcinogenic and classified by official organizations such as IARC Program. Consumers prefer kitchen utensils made of plastic, especially polyamides, for their ease of use and durability. Fifty-five samples of kitchen utensils were collected by retailers in Turkey. They were made of polyamide (40 samples), polypropylene (5 samples), polytetrafluoroethylene (5 samples), polyethylene (4 samples) and polystyrene (1 sample). Twenty targeted PAAs were analyzed in migration extracts using LC–MS/MS. Six PAAs-aniline (ANL), 4,4′-methylenedianiline (4,4′-MDA), 2,6-toluenediamine (2,6-TDA), 2,4-toluenediamine (2,4-TDA), 3,3′-dimethylbenzidine (3,3′-DMB), and o-toluidine (o-T) were detected in at least one of the 55 samples. ANL was the predominant PAAs in 20 samples below and above its limit of quantification (LOQ) values. The serving spoon (SS3 coded sample) had the highest aniline concentration at 0.057 mg/kg, followed by the crepe spatula (CS3) at 0.038 mg/kg. 4,4′-MDA and 3,3ˈ-DMB were detected below their LOQ values in four and only one of the samples. After the third migration test, no PAAs were detected in any sample. The detected PAA concentrations were low, suggesting a limited potential health risk for consumers under the tested migration conditions, although the presence of PAA highlights the importance of continued monitoring.
From private cars to micromobility: Network modeling and environmental assessment of short-distance trips in Izmir
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Öğütveren, Emre; Haldenbilen, Soner
Urban transportation systems face increasing sustainability challenges due to the dominance of private-car use, particularly for short-distance trips. This study investigates the potential of micromobility to replace private-car travel on short-distance journeys and evaluates the resulting impacts on urban transportation networks and environmental sustainability. The analysis focuses on the Bornova district of Izmir and is based on a face-to-face survey conducted with 502 private-vehicle users. Survey data were analyzed using descriptive statistics, chi-square tests and a binary logit regression model to identify factors influencing the willingness to adopt micromobility. Within the surveyed sample of private-car users, modal-shift rates were estimated as 35% for trips up to 5 km and 33% for trips between 5 and 10 km. These rates were applied to the private-car demand and distance matrices developed for the year 2030 within the scope of the Izmir Transportation Master Plan, resulting in a revised private-car demand matrix and a separate demand matrix representing potential micromobility users. Network assignments were performed in the PTV VISUM modeling environment. Assignment results demonstrate notable network-level changes following micromobility integration. The total length of road segments with micromobility traffic volumes exceeding a threshold of 10 veh/h was calculated at 292.5 km. Environmental impacts were evaluated using a life-cycle assessment (LCA) framework, revealing an approximate 5.5% reduction in total life-cycle CO2 emissions. Overall, the findings provide quantitative evidence supporting micromobility as an effective component of sustainable urban transport strategies and offer guidance for local governments in infrastructure planning and policy development.
Exogenous applied proline may enhance the tolerance of sweet sorghum (Sorghum bicolor (L.) Moench) under water deficit stress
(Universidad del Zulia, 2026) Taş, Timuçin; Babacan, Orkun; Işık, Yahya; Genç, Tülay Turgut; Güngör, Hüseyin
Drought is a major abiotic stress that threatens global food security by reducing crop yield and quality. Foliar application of osmoprotectants such as proline offers a promising means to mitigate drought-induced damage. This study examined the effects of exogenous proline (P0, P200, P400, and P600 mg.L-1), sorghum genotype, and their interaction on morphological, physiological, biochemical, forage quality, and microbial traits under different drought levels (I100, I75, I50, and I25). Proline application increased dry matter by over 100 % under medium to severe deficits and enhanced root dry weight by 90 % at 75 % water reduction. The strongest response occurred in chlorophyll content (SPAD), reflecting improved photosynthetic stability. Exogenous proline reduced leaf drying by 25 % and alleviated drought-related declines in forage quality, as evidenced by improvements in NDF, ADF, and ADL. It also boosted peroxidase activity more than superoxide dismutase and catalase, minimizing hydrogen peroxide (H₂O₂) toxicity and oxidative stress. Even under extreme drought (I25), proline maintained plant vigor and improved water-use efficiency by 25-40 % at the seedling stage. Compared with the control, leaf chlorophyll content (SPAD values) decreased by 13.91 %, 24.28 %, and 31.85 % under the I75, I50, and I25 treatments, respectively, suggesting that SPAD measurements at the seedling stage may serve as a practical and cost-effective indicator for identifying drought-tolerant sorghum genotypes.
ATP6V0A2-related cutis laxa: identification of a recurrent exon 16 deletion with founder effect in southeastern Turkiye and a novel frameshift variant
(John Wiley and Sons Inc, 2026) Esener, Zeynep; Habiloğlu, Esra; Ünal, Aysel Tekmenuray; Bolat, Gül Ünsel; Eşmeli, Figen; Sezer, Abdullah; Bulut, Edanur; Bolat, Hilmi
ATP6V0A2-related cutis laxa is a rare autosomal recessive disorder characterized by connective tissue abnormalities, developmental delay, and neurological features. While multiple sequence variants have been reported, exon-level deletions are rarely documented, and their clinical significance remains largely unknown. This study aims to present the clinical and molecular characteristics of a novel frameshift variant and recurrent exon 16 deletions in the ATP6V0A2 gene, to investigate a potential founder effect in southeastern Türkiye, and to contribute to the expanding genotype–phenotype correlation in ATP6V0A2-related cutis laxa. Ten cases from six unrelated families were evaluated. Exome sequencing, clinical exome sequencing, long-range polymerase chain reaction, gel electrophoresis, and haplotype analysis were performed. Variant interpretation followed ACMG and ClinGen guidelines. Clinical features were assessed through physical examination, developmental history, and neuroimaging. A novel homozygous frameshift variant (c.235del, p.Leu79Phefs*13) associated with severe neurological regression was identified in one case. Nine individuals carried a recurrent homozygous 380 bp deletion spanning exon 16 (c.1936-147_2055+113del). In our study, neurological regression—a feature rarely reported in the literature—was noted in two older patients. Haplotype analysis revealed shared homozygous regions in three cases, suggesting a founder effect. This cohort represents the largest reported series of ATP6V0A2-CL cases with exon 16 deletion to date. This study expands the genotypic and phenotypic spectrum of ATP6V0A2-CL and underscores the importance of copy number variation detection in next-generation sequencing-based diagnostics. The identification of a recurrent exon 16 deletion and shared haplotypes provides evidence for a founder effect in southeastern Türkiye and supports the implementation of population-specific screening for this variant.
Comparative pharmacokinetic dispositions of omeprazole and its metabolites following intravenous and oral administration in sheep and goats
(Bailliere Tindall Ltd, 2026) Kütahya, Zeynep Özdemir; Akyol, Büşra Aslan; Mamuk, Selen; Gökbulut, Cengiz
This study aimed to determine the pharmacokinetic behavior of omeprazole (OMP) and its metabolites in sheep and goats following both intravenous (IV) and oral (PO) administration. Twelve one-year-old female animals, comprising six Awassi sheep and six Alpine goats, were used to compare pharmacokinetic parameters after a single dose of OMP (1.0 mg/kg IV and 4.0 mg/kg PO). Plasma levels of OMP, hydroxyomeprazole (OMP‑OH), omeprazole sulfone (OMP‑Sulfone), and omeprazole sulfide (OMP‑Sulfide) were measured at specified time points. Results revealed that the pharmacokinetic profiles of OMP in sheep differed significantly from those in goats for both IV and PO routes. After IV administration, sheep showed greater systemic exposure (AUC0‑∞: 1.84 ± 0.38 µg·h/mL) and a longer elimination half-life (T1/2λz: 0.26 ± 0.05 h) compared to goats (AUC0‑∞: 0.67 ± 0.16 µg·h/mL; T1/2λz: 0.14 ± 0.03 h). Conversely, following PO administration, OMP bioavailability was low in both species, with sheep displaying an AUC0‑∞ of 0.81 ± 0.38 µg·h/mL (F %: 11.00) and goats 0.33 ± 0.21 µg·h/mL (F %: 12.31). Metabolites OMP‑OH and OMP‑Sulfone were not detected in plasma after PO dosing in either species. However, after IV dosing, metabolite levels were higher in sheep than in goats. Consequently, these findings may support the development of more rational therapeutic strategies for the use of OMP in small ruminant medicine.
