Balıkesir Üniversitesi Kurumsal Akademik Arşivi
DSpace@Balıkesir, Balıkesir Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Kayıt dışı ekonominin vergi gelirleri üzerindeki etkisi: Türkiye örneği (1995-2020)
(Özgür Yayınları, 2026) Sağdıç, Ersin Nail; Yıldız, Fazlı
Kayıt dışı ekonominin kamu maliyesi ve özellikle vergi gelirleri üzerindeki etkisinin belirlenmesi, etkin maliye politikalarının oluşturulması açısından önem arz etmektedir. Bu çalışma, 1995-2020 döneminde Türkiye’de kayıt dışı ekonominin vergi gelirleri üzerindeki etkisini zaman serisi ekonometrik yöntemleri kullanarak incelemektedir. Analizde serilerin durağanlık ve eşbütünleşme özellikleri test edilmiş, uzun dönem eşbütünleşme ilişkisi DOLS, FMOLS ve CCR tahmin yöntemleri ile incelenmiştir. Ulaşılan bulgular, kayıt dışı ekonominin vergi gelirleri üzerinde uzun dönemde negatif ve istatistiksel olarak anlamlı bir etkiye sahip olduğunu göstermektedir. Sonuçlar hem Türkiye hem de uluslararası literatürde yaygın olarak kabul gören, kayıt dışı ekonominin vergi gelirlerini azalttığı yönündeki ampirik bulguları desteklemektedir. Araştırma bulguları kayıt dışı ekonominin azaltılmasına yönelik politikaların vergi gelirlerinin artırılması ve mali sürdürülebilirlik açısından önemli olduğuna işaret etmektedir.
Savunma harcamalarının ekonomik büyüme üzerindeki etkisi: Türkiye örneği (1961-2024)
(Özgür Yayınları, 2026) Yıldız, Fazlı; Bozbay, Melih
Bu çalışmada, Türkiye ekonomisinde 1961-2024 döneminde savunma
harcamaları ile ekonomik büyüme arasındaki ilişki ARDL sınır testi yaklaşımı
ve Granger nedensellik testi kullanılarak incelenmiştir. Analiz sonuçları,
değişkenler arasında uzun dönemli bir ilişkinin varlığını ortaya koymaktadır.
Uzun dönem katsayı tahminlerine göre savunma harcamalarının ekonomik
büyüme üzerinde pozitif ve istatistiksel olarak anlamlı bir etkiye sahip olduğu
belirlenmiştir. Granger nedensellik testi bulguları ise savunma harcamalarından
ekonomik büyümeye doğru tek yönlü bir nedensellik ilişkisinin bulunduğunu
göstermektedir. Elde edilen bulgular, Türkiye’de savunma harcamalarının
ekonomik büyümeyi destekleyen önemli bir unsur olduğunu ortaya koymaktadır.
Evaluation of pyrazoline-bearing primary sulfonamides as potent inhibitors of lactoperoxidase
(Afyon Kocatepe Üniversitesi, 2026) Dedeoğlu, Nurcan; Demir, Ayşenur; Yamalı, Cem; Işık, Semra
Lactoperoxidase (LPO E.C. 1.11.1.7) is a glycoprotein belonging
to the class of oxidoreductases and constitutes a notable
member of the peroxidase enzyme family. The biological
significance of LPO is attributed to its role as a natural defense
system against microbial infection. In the current study, to
examine the inhibitory effects of 8 different polyfluorosubstituted pyrazoline-type primary sulfonamide derivative
compounds on LPO enzyme activity, LPO enzyme was extracted
from buffalo milk and purified using Sepharose 4B-etilendiamin4-tiyoüreido-benzensülfonamid affinity column, resulting in a
2212.45-fold purification, a 19.31 % yield, and a specific activity
of 4955.9 EU/mg. Ki values for the active inhibitors were
determined to be between 1.02±0.53-6.67±2.94 µM, while their
IC50 values were in the range of 0.144±0.03-0.798±0.07 µM. The
IC50 value and Ki values for the most effective inhibitor,
compound 3, were calculated as 0.144±0.03 and 6.06±4.06 µM,
respectively, and it was found that this compound inhibited LPO
enzyme activity non-competitively.
Ethnic, economic, and therapeutic applications of lichens as a source of bioactive secondary metabolites: An integrative review
(İzzet Kara, 2026) Sancak, Handan Kurtulmuş; Çobanoğlu, Gülşah
Interest in and research on lichens is increasing day by day due to their
benefits to human health and their uses in various fields. This study aims to reveal
the potential uses of lichens in human life, from traditional to modern, through a
broad literature review. Producing many unique secondary metabolites as a result
of their symbiotic lifestyle, lichens are among the natural resources used in various
fields such as medicine, pharmaceuticals, cosmetics, chemical dyes, textiles, and
the food industry. Their increasingly discovered biological effects—antifungal,
antibacterial, antioxidant, antitumor, anticarcinogenic, and antiviral—highlight the
significant potential of lichens in health biotechnology. Some lichens are known to
provide habitat material and food for various animals and are also consumed by
humans. Ethnic uses of lichens can be seen in mummification, traditional clothing,
costumes, and ornaments in various cultures from ancient times to the present.
Today, lichens are frequently encountered in artistic designs, accessories,
floriculture, terrariums, and decorative wall hangings. Historical medical research
has revealed various therapeutic uses of lichens. Many lichen species have been
documented as sources of active pharmaceutical ingredients in medicines and as
components of cosmetic products. Current studies on lichen extracts and lichen
secondary metabolites indicate that lichen species exhibit antibacterial,
antioxidant, antiviral, and antifungal activities, and have medical potential as
therapeutic agents against a variety of diseases. This review briefly examines the
biology and contributions of lichens to nature, followed by information on their
versatile uses from various sources dating back approximately 80 years.
Physical function and performance effects of platelet-rich plasma (PRP) in early-stage knee osteoarthritis
(Argist Yayıncılık, 2026) Atik, Aziz; Arı, Bünyamin; Kılıç, Ali İhsan
Aim: Osteoarthritis (OA) is a common, painful and degenerative joint disease that causes functional limitation. Pharmaceutical
agents, exercise, physical therapy, intra-articular injections and surgery can be counted among treatment applications. In recent
years, platelet-rich plasma (PRP) has been considered as an autologous biological therapy used to stimulate cartilage healing and
improve symptoms. Although the effects of PRP injection on pain and function of knee OA patients have been widely investigated
before, there have been very limited studies about the effects on physical function and performance. In this study, it was aimed to
investigate the effectiveness of PRP in improving physical function and performance in patients with knee OA.
Material and Methods: This study was performed with 80 stage 1-2 bilateral knee OA patients according to the Kellgren-Lawrence
Scale. Intra-articular PRP injection was applied by the same physician at one month intervals. Physical performances of the patients
were analyzed twice, just before the first injection and six months after the last injection, with Stair Climb Test (SCT), 50-Foot Walk
Test (50 FWT), 30-second Chair Stand Test (30 CST) and Timed Up and Go Test (TUG). In addition, Hospital for Special Surgery
(HSS) knee scoring was also recorded as secondary functional result criteria. Paired-t test was used to assess the significance of the
difference in before and after injection results.
Results: Statistically significant improvement was observed in all physical performance tests (SCT, 50 FWT, 30 CST, TUG) and functional scoring (HSS) at 6 months after PRP application (p<0.001).
Conclusion: PRP is a safe and effective autologous biological agent in improving physical function and performance in patients with
mild to moderate knee OA.
