Güncel Gönderiler: Temel Tıp Bilimleri
Toplam kayıt 322, listelenen: 241-260
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Nephrotoxic effects of varenicline as the most effective drug used for smoking cessation: A preliminary experimental study
(Springer, 2015)Varenicline is a new most effective drug for smoking cessation. Its effect on kidney functions remains unclear. This study purposed to investigate whether varenicline causes nephrotoxicity in rats. Fifteen rats were randomly ... -
Circulating levels of obestatin and copeptin in obese and nonobese women with polycystic ovary syndrome
(Elsevier Science BV, 2015)Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 58% of reproductive-age women. It is associated with insulin resistance, central obesity, type 2 diabetes mellitus, dyslipidemia, ... -
The protective effect of curcumin administration on carbon tetrachloride (ccl4)-induced nephrotoxicity in rats
(Polish Acad Sciences Inst Pharmacology, 2015)Background: The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective ... -
Selenium protects cerebral cells by cisplatin induced neurotoxicity
(Acta Cirurgica Brasileira, 2015)PURPOSE: To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. METHODS: Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin ... -
Simvastatin reduces VEGF and NO levels in acute stages of experimental traumatic brain injury
(Springer-Verlag Italia SRL, 2013)This study was undertaken to evaluate the effect of simvastatin, a cholesterol-lowering agent, on vascular endothelial growth factors (VEGFs), nitric oxide (NO) levels and neuroprotection, in rats with experimentally induced ... -
Protective effect of 2-aminoethyl diphenylborinate in rat colitis model induced by acetic acid
(E-Century Publishing Corp, 2016)Some of the diseases like ulcerative colitis, Crohn disease and certain types of intestinal cancers are not treatable effectively. Our aim was to investigate the protective effects of 2-aminoethyl diphenylborinate (2-APB) ... -
The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats
(Sage Publications Inc, 2016)Caffeic acid phenethyl ester (CAPE) has antioxidant and anti-inflammatory properties. The aim of this study is to examine the negative effects of toluene on kidney tissues and functions and to investigate the protective ... -
Effect of systemic medical ozone application on oxidative parameters in intestinal ischemia-reperfusion
(Wiley-Blackwell, 2014) -
Effect of chronic systemic nesfatin-1 treatment in intestinal ischemia/reperfusion
(Wiley-Blackwell, 2014) -
Potential role of some oxidant/antioxidant status parameters in prefrontal cortex of rat brain in an experimental psychosis model and the protective effects of melatonin
(Verduci Publisher, 2014)OBJECTIVES: The etiology of schizophrenia is unknown. However, some of the neuropathological changes in schizophrenia may be the result of increased free radical-mediated or reactive oxygen species (ROS) mediated neurotoxicity. ... -
Effects of epidermal growth factor (egf) on caıx and caxıı expression ın mg-63 cells
(Wiley-Blackwell, 2015)Carbonic anhydrases catalyse the reversible reaction from H2Oand CO2to HCO3-ions. Carbonic Anhydrase IX and CarbonicAnhydrase XII are member of the carbonic anhydrase family.Carbonic Anhydrase IX and Carbonic Anhydrase XII ... -
The determination of effect of some antibiotics on paraoxonase 2 (PON2) enzyme activities in human macrophages cell
(Wiley-Blackwell, 2015)The human paraoxonase (hPON) gene family includes threemembers: PON1, PON2, and PON3, located adjacent to eachother on the long arm of chromosome 7. The three hPONs shareapproximately 65% identity at the amino acid level ... -
The effects of ex vivo ozone treatment on erythrocyte carbonic anhydrase enzyme
(Wiley-Blackwell, 2015)AIM: Medical ozone generates beneficial effects by stimulating the endogenous antioxidant systems. Carbonic anhydrases (CAs, EC 4.2.1.1.) are metalloenzymes and play a significant role in acid-base regulation. The aim of ... -
The melatonin attenuates alloxan ınduced post-diabetic testicular damage and oxidative effects in rats
(Kafkas Univ, 2015)The aim of this study was to examine the protective effect of melatonin (MLT) on the alloxan-induced post-diabetic testicular damage in rats. Forty-eight Sprague Dawley male rats were divided into four groups (n = 12). ... -
Effects of dietary boron and phytase supplementation on growth performance and mineral profile of broiler chickens fed on diets adequate or deficient in calcium and phosphorus
(Taylor & Francis Ltd, 2015)1. Two experiments were designed to determine the effect of dietary boron (B) in broiler chickens. In Experiment 1, a 2x4 factorial arrangement of treatments was used to investigate the effect of dietary calcium (Ca) and ... -
Single dose varenicline may trigger epileptic activity
(Springer-Verlag Italia Srl, 2014)Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly ... -
Histopathological changes in rat pancreas and skeletal muscle associated with high fat diet induced insulin resistance
(Taylor & Francis Ltd, 2015)The effects of a high fat diet on the development of diabetes mellitus, insulin resistance and secretion have been widely investigated. We investigated the effects of a high fat diet on the pancreas and skeletal muscle of ... -
Prevention of ovarian hyperstimulation syndrome in a rat model: comparison of the efficacy of tocilizumab with that of ranibizumab, cabergoline, and a gonadotropin-releasing Hormone antagonist
(Taylor & Francıs Ltd, 2015)The aim of the study is to investigate the effects of the interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, a gonadotropin-releasing hormone antagonist (GnRHA), and ...
