Temel Tıp Bilimleri: Recent submissions
Now showing items 1-20 of 319
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Atlas-based structural analysis of prefrontal cortex atrophy in major depressive disorder: Correlations with severity and episode frequency
(Elsevier Ireland Ltd, 2024)Background: Current models of major depressive disorder (MDD) primarily focus on the structural and functional changes in key prefrontal areas responsible for emotional regulation. Among these regions some sections such ... -
Oral microbial dysbiosis in patients with oral cavity cancers
(Springer Heidelberg, 2024)Objectives The pathogenesis of oral cavity cancers is complex. We tested the hypothesis that oral microbiota dysbiosis is associated with oral cavity cancer. Materials and methods Patients with primary oral cavity cancer ... -
Oncostatin M is related to polycystic ovary syndrome-case control study
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)Background: Oncostatin M, a novel adipokine, plays a role in oogenesis, lipogenesis, and inflammation and may contribute to polycystic ovary syndrome pathogenesis and related metabolic problems. Adipokines are believed to ... -
Preconditioning of human umbilical cord mesenchymal stem cells with deferoxamine potentiates the capacity of the secretome released from the cells and promotes immunomodulation and beta cell regeneration in a rat model of type 1 diabetes
(Elsevier, 2024)This study aimed to examine the effects of the secretome released by human umbilical cord-mesenchymal stem cells (MSC) as a result of preconditioning with deferoxamine (DFX), a hypoxia mimetic agent, on type 1 diabetes ... -
Evaluation of the association of serum sclerostin and carotid intima media thickness with chronic kidney failure and kidney transplantation
(Taiwan Society of Geriatric Emergency and Critical Care Medicine (TSGECM), 2024)Purpose: This study aimed to determine the serum sclerostin levels in kidney transplant recipients, dialysis patients, and patients with non-dialysis chronic kidney disease (CKD), and evaluate their associations with carotid ... -
Neuroprotective effects of Sideritis trojana essential oil in AlCl3-induced amnesic rats
(Har Krishan Bhalla and Sons, 2024)In this study, the effects of Sideritis trojana essential oil on memory, anxiety, and depression were investigated in rats subjected to AlCl3-induced dementia. The major constituents of S. trojana essential oil were analyzed ... -
In vitro and in silico investigations of the pro-apoptotic activity of Opuntia ficus-indica cladode extracts against K562 cells
(Walter De Gruyter GMBH, 2024)Objectives: Cladodes of Opuntia ficus-indica (OFI) are thought to be an excellent source of bioactive compounds, making them an aspirant for the manufacture of health-promoting compounds. This study aims at exploring the ... -
Could hepcidin be a new biomarker in patients with idiopathic pulmonary fibrosis (IPF)?
(MDPI, 2024)Hepcidin is a biomarker produced by hepatocytes in chronic disease anemia and is known to increase during chronic inflammation. This study compares the hepcidin levels in idiopathic pulmonary fibrosis (IPF) patients and ... -
Effects of chronic intermittent cold stress on anxiety-depression-like behaviors in adolescent rats
(Elsevier, 2024)Stress, which triggers numerous physiological and behavioral responses in the organism, is a significant risk factor that contributes to the development of psychiatric disorders such as depression and anxiety. This study ... -
Darbepoetin alpha has an anxiolytic and anti-neuroinflammatory effect in male rats
(BMC, 2024)Aims We aimed to investigate the anxiolytic effect of darbepoetin alpha (DEPO), an erythropoietin derivative, in a neuroinflammation model regarding different behaviors and biological pathways. Methods Forty adult male ... -
Effect of high-intensity interval training on self-care and anxiety-like behaviors in naive rats
(Springer, 2024)Self-care behavior covers individual's health, life and well-being to maintain the necessary activities. The aim of this study is to examine the self-care and possible anxiolytic efects of high-intensity interval exercise ... -
Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors
(Elsevier, 2024)Aim: The secretome of mesenchymal stem cells (MSCs) could be a potential therapeutic intervention for diabetes and associated complications like nephropathy. This study aims to evaluate the effects of conditioned ... -
Effects of coenzyme Q10, fullerene C60, and αlpha-lipoic acid on histomorphometric, antiapoptotic and ınsulin expression in pancreatic tissue of rats exposed to bisphenol A
(Prof.Dr. Mustafa İssi, 2024)The aim of this study was to determine the morphometric changes in the pancreas, apoptosis related pancreatic damage, and differences in insulin expression in male rats exposed to low doses of BPA from early pubertal ... -
Evaluation of serum magnesium levels in patients with the diagnosis of depressive disorder applied to a psychiatry clinic: A retrospective study
(Balıkesir Üniversitesi, 2024)Objective: The role of magnesium in the pathophysiology of depression has increased the interest in magnesium. Therefore, in this study, we aimed to evaluate serum magnesium levels in patients diagnosed with depressive ... -
The relationship between physical activity and cognition in Kırşehir Ahi Evran University medical faculty students
(Ahi Evran Üniversitesi Tıp Fakültesi, 2024)Purpose: Due to the difficulty and intensity of medical school education, medical students often lead a sedentary lifestyle. As seen in different methodological studies, physical activity affects cognitive functions. Few ... -
Choice of empirical treatment in patients with wound infection
(Marmara Üniversitesi, 2024)Objective: We aimed to determine the distribution of infectious agents in wound culture specimens, their resistance rates, and to evaluate empirical treatment choices in wound infections. Methods: Wound culture results of ... -
Protective effect of pomegranate juice on lead acetate-induced liver toxicity in male rats
(Pera Yayıncılık, 2024)Objective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In ... -
Hibrit gümüş nanoparçacık komplekslerinin sitotoksik ve antilayşmanyal aktivitesinin araştırılması: Leishmania türlerine karşı potansiyel ilaç adayları
(Bilimsel Tıp Yayınevi, 2024)Son yıllarda mevcut ilaçlara dirençli Leishmania türlerinin izole edilmesi, ilaç adayı olabilecek alternatif moleküllerin araştırılmasını zorunlu hale getirmiştir. Bu çalışmada, hibrit gümüş nanoparçacık (AgNP) komplekslerinin ... -
Tehlikeli bir ilişki: Yurt dışı kaynaklı plasmodium falciparum ve salmonella typhi koenfeksiyonu olgusu
(Galenos Yayınevi, 2024)Sıtma, çoğunlukla anofel cinsi dişi sivrisineklerin insanları sokması ile bulaşan paraziter bir hastalıktır. Ülkemizdeki yerli sıtma olgusu bildirimi Dünya Sağlık Örgütü kayıtlarında görülmemekle birlikte, yurt dışı ... -
Volumetric evaluation of substantia nigra in major depressive disorder using atlas-based method
(Effect Publishing Agency ( EPA ), 2024)Aim: The substantia nigra pars compacta (SNc), a vital part of the brain that produces dopamine, is being closely studied due to its potential role in the monoamine hypothesis, which aims to explain the causes of Major ...
