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dc.contributor.authorÇitil, Mehmet
dc.contributor.authorTunca, Recai
dc.contributor.authorUzlu, Erdoğan
dc.contributor.authorKarapehlivan, Mahmut
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorYapar, Kürşad
dc.contributor.authorEroğlu, Hüseyin Avni
dc.date.accessioned2024-01-24T08:50:55Z
dc.date.available2024-01-24T08:50:55Z
dc.date.issued2022en_US
dc.identifier.issn2548-1150
dc.identifier.urihttps://doi.org/10.31797/vetbio.1136444
dc.identifier.urihttps://hdl.handle.net/20.500.12462/13834
dc.descriptionUzlu, Erdoğan (Balikesir Author)en_US
dc.description.abstractObesity and fatty liver is a worldwide health problem in human with detrimental consequences where many investigations are undertaken to overcome this problem. In this study, gemfibrozil and L-carnitine were evaluated in prevention of obesity and lipidosis. The study involved 56 New-Zealand Albino rabbits, divided into 8 equal groups (n=7). The groups were as follow; group I (normal diet), II (normal diet +gemfibrozil), III (normal diet+L-carnitine) and IV (normal diet+gemfibrozil+L carnitine), V (high fat diet), VI (high fat diet+gemfibrozil), VII (high fat diet+L carnitine) and VIII (high fat diet+gemfibrozil+L-carnitine). Animals were blood sampled and wieght weekly during the experiment and at the end of the experiment for determination of biochemical parameters (glucose, total lipid). All rabbits were euthanised for histopathological examination and for distrubition of peroxisome proliferator activated receptors (PPARs) in tissues by immunohystochemistry. Gemfibrozil and L-carnitin treatment in rabbits given high fat diet resulted in statistically significant decrease in total lipid when compared to those only received high fat diet. Beta oxidation of high fat diet group was significantly higher than that of groups additionally received gemfibrozil and L-carnitine. Immunohistochemistry revealed an increase in PPAR, PPAR-α and β but not PPAR-γ expression in high fat diet group. On the contrary, L-carnitin administration had no effect on tissue PPAR expression. PPAR-α expression differed between groups received gemfibrozil and high fat diet and those did not. The most marked macroscopy finding was abdominal fat increase in high fat diet group (group V). On the other hand gemfibrozil administration resulted in significant abdominal fat decrease. Furthermore decreased abdominal fat was marked in gemfibrozil and L-carnitine given animals (group VIII) when compared to other groups. In conclusion, gemfibrozil and L-carnitine administration alleviated abdominal and hepatic fattening. Gemfibrozil also caused a significant increase in PPAR-α expression in the liver. It may be of use in avoiding abdominal fat (obesity) due to high fat diet by use of gemfibrozil, a synthetic PPAR-a ligand, and L-carnitine.en_US
dc.language.isoengen_US
dc.publisherİlker Çamkertenen_US
dc.relation.isversionof10.31797/vetbio.1136444en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectGemfibrozilen_US
dc.subjectL-carnitineen_US
dc.subjectObesityen_US
dc.subjectPPARsen_US
dc.subjectRabbitsen_US
dc.titlePathological and biochemical investigation of the effects of l-carnitine and gemfibrozil on peroxisome proliferator activated receptors (PPARS) and lipidosis in rabbits on a high-fat dieten_US
dc.typearticleen_US
dc.relation.journalJournal of Advances in Vetbio Science and Techniquesen_US
dc.contributor.departmentVeteriner Fakültesien_US
dc.contributor.authorID0000-0001-9839-7533en_US
dc.contributor.authorID0000-0003-0004-7485en_US
dc.contributor.authorID0000-0002-3064-6633en_US
dc.contributor.authorID0000-0003-0408-534Xen_US
dc.contributor.authorID0000-0002-8004-7364en_US
dc.contributor.authorID0000-0003-0287-4521en_US
dc.contributor.authorID0000-0002-1040-3255en_US
dc.identifier.volume7en_US
dc.identifier.issue3en_US
dc.identifier.startpage346en_US
dc.identifier.endpage360en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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