Yazar "Türkoğlu, Sümeyye Aydoğan" için listeleme
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ADAMTS1 promotorunun SMAD aracılı regülasyonunun incelenmesi
Poyrazlı, Fatma (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2016)ADAMTS1 (ADAM metallopeptidase with thrombospondin type I motif, 1), ADAMTS ailesinin ilk örneğidir ve Kuno ve arkadaşları tarafından fare ADAMTS1 geninin karakterizasyonu 1997 yılında yapılmıştır. ADAMTS1, endotel hücre ... -
ADAMTS2 geninin klonlanması ve ekspresyonu
Gültekin, Arife Sinem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2017)ADAMTS’ler (A Disintegrin and Metalloproteaz With Trombospondin Motifs; Trombospondin Motifli Matriks Metalloproteazlar) dokuların yeniden düzenlenmesi, pıhtılaşması, matriks yapımı ve yıkımı gibi fizyolojik olaylarda rol ... -
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, beta-lactamase enzyme inhibition studies
Önder, Ferah Cömert; Ay, Mehmet; Türkoğlu, Sümeyye Aydoğan; Koçkar, Feray Tura; Çelik, Ayhan (Taylor & Francis Ltd, 2016)The aims of this study were to examine the antiproliferation of Humulus lupulus extracts on human hepatoma carcinoma (Hep3B) and human colon carcinoma (HT-29) cell lines along with enzyme inhibitory effects of the crude ... -
Are reference genes, GAPDH, beta-Actin and H-beta-2-microgloblin affected under normoxic and hypoxic conditions in Hep3B cells?
Türkoğlu, Sümeyye Aydoğan; Sunay, B.; Yıldırım, Hatice Kalkan; Köçkar,Feray (Wiley-Blackwell, 2011)Abstract:The appropriate choice of an internal standard is criti-cal for quantitative RNA analyses. As housekeeping genes, glyc-eraldehyde-3-phosphate dehydrogenase (GAPDH),b-Actin andH-b-2-Microgloblin are commonly employed ... -
The bioinformatic and expression analysis of PSMD4 gene
26S proteasome non-ATPase subunit 4 (PSMD4) that has a molecular weight of 41 kDa is included on chromosome 1 (1q21.3). PSMD4 protein is a subunit of the 19S regulatory region in the 26S proteasome. The proteasome breaks ... -
Carbonic anhydrase III is a new target of HIF1 alpha in prostate cancer model
Okuyan, Derya; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Elsevier, 2020)Carbonic Anhydrase III (CAIII) belongs to a member of the alpha Carbonic Anhydrase (CA) family. Although some CA members are strongly up-regulated by HIF1-alpha, it is not known about the transcriptional regulation of CAIII ... -
The chemical components, antioxidant and anticancer activities of ziziphus jujube extracts from Turkey
Türkoğlu, Sümeyye Aydoğan; Çarıkçı, Sema (Agrimedia GMBH, 2020)The bioactive components which are nutritionally and medically important of jujube fruit have been shown to vary with growing conditions. In this study, the cytotoxic effect of Ziziphus jujube fruit, which is in two different ... -
Cloning of ADAMTS2 gene and colony formation effect of ADAMTS2 in Saos-2 cell line under normal and hypoxic conditions
Türkoğlu, Sümeyye Aydoğan; Tosun, Sinem Gültekin (Adıyaman Üniversitesi, 2020)ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2), an N- propeptidase isoenzyme, is an enzyme involved in collagen biosynthesis by providing the amino ends of procollagen to be cut away. ADAMTS2 ... -
Development and characterization of superparamagnetic nanomaterial to determine its potential application in removing the bitterness of table olives
Savaş, Elif; Karaağaç, Öznur; Köçkar, Hakan; Kaya, Mihrap Yaşar; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (MYU, 2020)The aim of this study is to develop stable superparamagnetic iron oxide nanoparticles (SPIONs) for the immobilization of beta-glucosidase. The goal is to figure out the possibility of applying immobilization techniques in ... -
Effects of IL-6 and TNF-α cytokines on cell proliferation in androgen dependent/independent prostate cancer cell lines
Onat, Serhad; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Çanakkale Onsekiz Mart University, 2024)Abstract − Prostate cancer is the second most common types of cancer among men worldwide. Prostate cancer, caused by abnormal and uncontrolled growth of the cells that make up the prostate tissue, is second only to ... -
The effects of TNF-alpha on ADAMTS-1 and VEGF gene expressions in HEP3B cells
Sunay, Fatma Bahar; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Wiley-Blackwell, 2012)Angiogenesis is essential for tumor growth, progression andmetastasis. Angiogenesis is controlled by several endogenousstimulators and inhibitors. Among these stimulators, the vascularendothelial growth factor (VEGF) owns ... -
Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
Yücetürk, Selma Çelen; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray; Küçükbay, Fatümetüz Zehra; Azaz, Ayşe Dilek (Walter De Gruyter GMBH, 2021)In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using ... -
Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II
Gökçe, Başak; Gençer, Nahit; Arslan, Oktay; Türkoğlu, Sümeyye Aydoğan; Alper, Meltem; Köçkar, Feray (Informa Healthcare, 2012)The in vitro effects of the injectable form of analgesic drugs, dexketoprofen trometamol, dexamethasone sodium phosphate, metamizole sodium, diclofenac sodium, thiocolchicoside, on the activity of purified human carbonic ... -
Expression of carbonic anhydrase III (CAIII) from different cell lines
Okuyan, D.; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Wiley-Blackwell, 2011)Carbonic anhydrase III (CAIII, Carbonate Dehydratase EC 4.2.1)is an abundant cytoplasmic protein found in skeletal muscle, liver,and adipocytes. It is distinguished from other members of the CAfamily by characteristics ... -
Hipoksi ve kanser
Türkoğlu, Sümeyye Aydoğan; Poyrazlı, Fatma; Okuyan, Derya; Köçkar, Feray (Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü, 2021)Dokudaki gerekli oksijen seviyesinin normal değerin altına düşmesi hipoksi olarak tanımlanır. Hipoksi katı tümörlerde sık karşılaşılan bir durumdur. Tümör hücreleri yeterli oksijen alamadığında hücre ölümüne gitmeden ... -
Hipoksik koşullarda farklı hücre hatlarında ve C.Elegans' da karbonik anhidraz VII, karbonik anhıdraz VII benzeri genlerin regülasyonu
Bozkurt, Aysu (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2023)Karbonik anhidraz (CA)’lar karbondioksit hidrasyonunun ve dehidrasyonun tersine çevrilebilir bir reaksiyonunu katalize ederler böylece asit-baz ve iyon düzenlenmesini sağlayarak metabolik süreçlerde hayati bir rol oynarlar. ... -
Hypoxic regulation of the klk4 gene in two different prostate cancer cells treated with TGF- β
Poyrazlı, Fatma; Okuyan, Derya; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Springer, 2024)The human kallikrein-related peptidase (KLK) family which consists of 15 members is associated with prostate cancer and other cancers. It has been reported that overexpression of KLK4 in prostate cancer correlates with ... -
Inhibition studies on mutant Phe91Asn human carbonic anhydrase I (HCA I) gene
Köçkar, Feray; Ayduen, M.; Türkoğlu, Sümeyye Aydoğan; Arslan, Oktay; Turan, Yusuf (Wiley-Blackwell, 2008)Carbonic anhydrases (CAs; carbonate dehydratases EC 4.2.1.1) are ubiquitous metalloenzymes present in prokaryotes and eukaryotes that and encoded by four evolutionarily different gene families. In mammals, 15 a-CA isozymes ...
