Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome

Abstract

Uncombable hair syndrome (UHS), also known as “spun glass hair syndrome,” “pili trianguli et canaliculi,” or “cheveux incoiffables” is a rare anomaly of the hair shaft which occurs in children and improves with age. UHS is characterized by dry, frizzy, spangly and often fair hair that is resistant to being combed flat.