Synthesis, complexation, and biological activity studies of 4-aminomethyl-7,8-dihydroxy coumarines and their crown ether derivatives

Abstract

The article focuses synthesis of novel 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca(2+), Mg(2+), Fe(2+), Zn(2+), Ni(2+), Cd(2+), Co(2+), and Mn(2+) ions at 25 degrees C +/- 0.1 with the 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma-Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity.