Comparison of instilled lidocaine and procaine effects on pain relief in dogs undergoing elective ovariohysterectomy

Abstract

The aim of the present study was to compare the analgesic efficacy of instilled intra-peritoneal lidocaine and procaine during the perioperative and the postoperative periods in dogs undergoing elective ovariohysterectomy (OVH). Twenty-four sexually intact female dogs were referred for OVH. Following the laparotomv procedure the L group received intraperironeal instillation of 3.5 mg/kg of 0.2% lidocaine. The therapeutic agent was administreted over the area of ovaries, broad ligament, and uterine stump. It was injected using a syringe and needle (23 G). The P group administered intraperitoneal instillation of 3.5 mg/kg of 0.2% procaine and the control group received 1.75 ml/kg of intraperitoneal saline in a similar fashion. Groups L and P had significantly lower Glascow Composite Measure Pain Scale scores (CMPS-SF) than the control group at the 0.5, 1,2, 3, 8, and 24 hour postoperative periods. In conclusion, administerstration of intraperitoneal installation of lidocaine and procaine were shown to provide a milady significant effect in reducing intraoperative and postoperative pain and biochemical stress responses within 3 hours of surgery.