Orexins increase penicillin-induced epileptic activity

Basit Öğe Kaydı
dc.authorid0000-0002-7884-5623en_US
dc.contributor.authorKortunay, Selim
dc.contributor.authorErken, Haydar Ali
dc.contributor.authorErken, Gülten
dc.contributor.authorGenç, Osman
dc.contributor.authorŞahiner, Melike
dc.contributor.authorTurgut, Sebahat
dc.contributor.authorTurgut, Günfer
dc.date.accessioned2019-10-17T11:56:38Z
dc.date.available2019-10-17T11:56:38Z
dc.date.issued2012en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionErken, Gülten (Balikesir Author)en_US
dc.description.abstractOrexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G.en_US
dc.description.sponsorshipPamukkale University - 2003SBE001en_US
dc.identifier.doi10.1016/j.peptides.2012.02.013
dc.identifier.endpage422en_US
dc.identifier.issn0196-9781
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84859432223
dc.identifier.scopusqualityQ2
dc.identifier.startpage419en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2012.02.013
dc.identifier.urihttps://hdl.handle.net/20.500.12462/8815
dc.identifier.volume34en_US
dc.identifier.wosWOS:000303181600020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectEEGen_US
dc.subjectEpilepsyen_US
dc.subjectOrexinen_US
dc.subjectPenicillinen_US
dc.subjectPower Spectrumen_US
dc.subjectSeizureen_US
dc.titleOrexins increase penicillin-induced epileptic activityen_US
dc.typeArticleen_US

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