Uric acid: A novel prognostic marker for cardiovascular disease

Abstract

Oxidative stress plays an important role in the development of endothelial dysfunction. The two important systems generating vascular oxidative stress are the nicotinamide adenine dinucleotide phosphate oxidase and the xanthine oxidase (XO) pathways. XO is an enzyme that produces uric acid (UA) during purine catabolism, and oxygen free radicals are generated [1]. Thus, the UA reflects level of oxidative stress