Comparison of the effects of Crystalin® spray and Froximun® powder on the healing of open wounds in cats and dogs

Abstract

Many topical products are recommended to accelerate wound healing, particularly for patients with chronic or non-healing wounds or when factors delaying healing are present. The potential benefits of these products must outweigh their cytotoxic effects. Hypochlorous acid and clinoptilolite are commonly used for this purpose. This study aimed to comparatively evaluate the effects of Crystalin® Spray and Froximun® Powder, containing these active ingredients, on wound healing. The study involved 12 owned animals (cats and dogs) of various ages, breeds, sexes, and weights. The animals were divided into two groups and treated with either Crystalin® Spray or Froximun® Powder. Wound healing in the Crystalin® Spray group was analyzed using Friedman’s test, revealing significant daily wound area reduction (p=0.001). Statistically significant healing was observed as early as the 19th day (p<0.05). Similarly, the Froximun® Powder group showed significant wound area reduction (p=0.001). However, a comparison between the two groups revealed no statistically significant difference in wound healing rates (p>0.05). While both products demonstrated effectiveness, Hypochlorous acid preparations offer a cost-effective option for prolonged treatment and are easier for both veterinarians and pet owners to apply. Conversely, clinoptilolite in powder form requires bandaging for effective application, which may pose challenges for pet owners to maintain treatment continuity outside clinical settings.