Creutzfeldt-Jacob's Disease Presenting with Psychiatric Symptoms and Severe Itching

Abstract

Creutzfeldt-Jacob's disease is a rare and fatal neurodegenerative disease characterized by the accumulation of abnormal prion-like proteins in the central nervous system. Clinical features, electroencephalography (EEG), magnetic brain resonance imaging (MRI) and protein 14.3.3 is used in diagnosis. Protein 14.3.3 may be negative in the early or late stages of the disease. Presentation with psychiatric symptoms and itching is not typical in the onset of the disease. Here we present a patient who was first admitted to the pschiatry clinic due to his psychiatric symptoms and had severe itching resistant to antihistamine treatment.