The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity

Abstract

Aim: The aim of this study was to determine the effects of quercetinon antioxidant system and some blood parameters inrats exposed to acute cadmium toxicity.Materials and Methods: Adult male “Wistar-Albino” rats (n= 30) were used and divided into four groups as Control (C, n= 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium+ Quercetin (Cd + Q, n = 8). Cadmium chloride (CdCl2, 4 mg/kg daily, s.c) were administrated to Cd and Cd+Q groups, andQuercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd + Qgroups for 3 days, respectively. Control group was not recievedany treatment. Blood samples were collected from all animalsat fourth day after treatments.Results: The levels of serum SOD, MDA, GSH, catalase, andplasma ALT, AST, GGT, total protein, albumin were detected.Although, serum MDA levels were found higher (P< 0.05) inCd than the other groups, it was similiar in Q and C groups.ALT, AST and GGT enzyme levels were observed higher in Cdthan C and Q groups (P< 0.05).Conclusion: Negative effects of acute cadmium toxicity onantioxidan system and some hematological parameters wereameliorated with quercetin treatment in rats.