Cloning and sequence analysis of the human CA9 promoter

Abstract

Carbonic anhydrases (CAs) are a group of zinc-containing metalloenzymes that catalyse the reversible reaction from H2O and CO2 to HCO3 - ions. There are fifteen mammalian CA isozymes with different tissue distributions and locations. Of the fifteen isozymes, CA IX has been linked to the tumors and neoplastic invasion.