Paraoxonase activities, total sialic acid concentration and lipid profile after use of controlled ınternal drug release (CIDR) in Gurcu goats

Abstract

The purpose of this study was to determine the effect of the use of controlled internal drug release (CIDR) in Gurcu goats for estrus synchronization on paraoxonase activity (PON1), total sialic acid (TSA) concentration and lipid profile. In the study, 50 Gurcu goats were examined. On day 9, 400IU pregnant mare serum gonadotropin and 5mg dinoprost tromethamine were injected. On day 11, CIDR was removed. Following estrus detection, goats on estrus mated with fertility proven Gurcu bucks (mating day). Biochemical analyses were conducted with samples taken on day 0, day 11 and mating day. An increase in TSA concentration and a decrease in PON1 activity was detected according to synchronization days (day 0, day 11 and mating day). A decrease was found in total cholesterol (TC), triglycerides and high-density lipoprotein concentrations. On day 11, an increase in TSA concentration and a decrease in PON1 activity was detected compared to control group. According to synchronization days (day 0, day 11, mating day), it was determined that TSA concentration increased in pregnant and non-pregnant goats (P=0.007 and P=0.013, respectively) and PON1 activity decreased (P=0.004). A negative correlation was determined between PON1 and TC (r=-401, P<0.05). In conclusion, CIDR treatment caused changes in PON1 activity, TSA concentration and lipid profile, on the other hand, did not negatively affect fertility.