Synthesis and characterization of poly(acrylic acid)/nanohydroxyapatite nanocomposite hydrogels and evaluation of its antibacterial, bio- and hemo-compatibility characteristics

Abstract

PAA/nHAp was synthesized by solvent casting method and characterized by different techniques. nHAp was homogeneously dispersed in nano-sized in PAA matrix. The thermal properties and glass transition temperatures of nanocomposites were improved. Nanocomposites blocked UV-visible light more than PAA. The swelling capacities of PAA and its nanocomposites increased with increasing time. The swelling capacities of nanocomposites were two or three times higher than that of PAA and decreased with increasing nHAp content and decreasing pH. The experimental data showed a very good agreement with second-degree kinetic equation. The antibacterial and biocompatibility properties of nanocomposites increased with increasing nHAp content.