The effect of combined exercises and consumption of mulberry leaf extract on serum inflammatory markers level in elderly type 2 diabetes mellitus men

Abstract

Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM). Materials and Methods : 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes. Results : The results showed that the amount of salusinβ and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusinα increased significantly in the training ( P= 0.001), training + supplement ( P= 0.001) and supplement ( P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusinβ and interleukin 6 were lower ( P= 0.001), and the level of salusinα was higher significantly in the training ( P= 0.001), training +supplement ( P= 0.001), and supplement ( P= 0.001) groups compared to the control groups. Conclusion : It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.