In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase

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dc.contributor.authorKaya, Mustafa Oğuzhan
dc.contributor.authorGül, Gülşah Çelik
dc.contributor.authorKurtuluş, Figen
dc.date.accessioned2019-09-09T11:43:43Z
dc.date.available2019-09-09T11:43:43Z
dc.date.issued2017en_US
dc.departmentFakülteler, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionGül, Gülşah Çelik (Balikesir Author)en_US
dc.description.abstractXanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC 50 constants for inhibition of XO. Among the synthesized compounds, Cu-V-O was found to be the most active (IC 50 = 7.119 mM) for inhibition of XOen_US
dc.identifier.doi10.14715/cmb/2017.63.12.7
dc.identifier.endpage28en_US
dc.identifier.issn0145-5680
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85039987094
dc.identifier.scopusqualityQ4
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.12.7
dc.identifier.urihttps://hdl.handle.net/20.500.12462/6301
dc.identifier.volume63en_US
dc.identifier.wosWOS:000419272800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherCellular and Molecular Biology Associationen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIC 50en_US
dc.subjectInhibitionen_US
dc.subjectTransition Metalen_US
dc.subjectVanadiumen_US
dc.subjectXanthine Oxidaseen_US
dc.titleIn vitro effects of novel type M-V-O derivatives on Xanthine Oxidaseen_US
dc.typeArticleen_US

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