Paraoxonase Enzyme Activity and Determination of Phenotypic Polymorphism in Patients with Acne Vulgaris

Abstract

Aim: This study aims to compare serum paraoxonase 1 (PON1) activity between patients diagnosed with acne vulgaris (AV) and a healthy control group, and to determine the PON1 phenotype. Materials and Methods: The study sample consists of 50 patients with moderate to severe AV who presented to the Clinic of Dermatology at Bal & imath;kesir University Faculty of Medicine. Additionally, healthy volunteers (n = 52) with similar age and gender characteristics to the patient group were included as the control group. The diagnosis of AV was made using the Global Acne Grading System. The serum PON1 activities in both AV patients and healthy volunteers were measured by spectrophotometric methods, and statistical comparisons were made among the groups. Furthermore, the PON1 phenotypic polymorphism was determined. Results: In our study, serum PON1 activity levels were found to be significantly lower in AV patients (36,149 +/- 14,536) compared to the control group (48,173 +/- 18,753) (P = 0.001). The distribution of PON1 phenotypes demonstrated a trimodal pattern. In the patient group, the QQ phenotype was observed in 48%, odds ratio in 24%, and risk ratio in 28%. In the control group, these rates were 5.8%, 44.2%, and 50%, respectively. Conclusion: The notably reduced activity of the antioxidant enzyme PON1 in patients with AV, as compared to the control group, indicates that oxidative stress could be a significant factor in its etiopathogenesis.