Relationship Between Morning Blood Pressure Surges and Peripheral Inflammatory Biomarkers in Parkinson's Disease

Abstract

Background: Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder, often resulting in blood pressure abnormalities due to autonomic dysfunction. The early morning rise in blood pressure, referred to as the morning surge, has been associated with various cardiovascular diseases when exaggerated. This study aims to investigate the relationship between morning blood pressure surge (MBPS) and inflammatory markers in patients with PD. Methods: In this retrospective study, we employed 24 h ambulatory blood pressure monitoring alongside the fibrinogen-to-albumin ratio and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers. The study included fifty idiopathic PD patients and fifty age- and sex-matched control subjects. MBPS was defined as the difference between morning blood pressure (measured two hours after awakening) and the lowest recorded nighttime blood pressure. Body mass index (BMI) was considered as an independent variable. Results: Our study found that morning blood pressure surge (MBPS) levels were significantly higher in Parkinson's disease (PD) patients compared to the control group, suggesting possible autonomic involvement. Conclusions: MBPS may indicate autonomic involvement, potentially contributing to cardiovascular and cerebral morbidity and mortality in PD patients. Longitudinal studies with larger sample sizes are warranted to further elucidate this relationship.