Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide
| dc.authorid | 0000-0001-8933-4944 | en_US |
| dc.contributor.author | Demirci, Tuna | |
| dc.contributor.author | Arslan, Mustafa | |
| dc.contributor.author | Bilen, Çiğdem | |
| dc.contributor.author | Demir, Dudu | |
| dc.contributor.author | Gençer, Nahit | |
| dc.contributor.author | Arslan, Oktay | |
| dc.date.accessioned | 2019-10-17T11:04:52Z | |
| dc.date.available | 2019-10-17T11:04:52Z | |
| dc.date.issued | 2014 | en_US |
| dc.department | Fakülteler, Fen-Edebiyat Fakültesi, Kimya Bölümü | en_US |
| dc.description | Bilen, Çiğdem (Balikesir Author) | en_US |
| dc.description.abstract | 1,3-Dicarbonyl derivatives of methylaminobenzene-sulfonamide were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and hCA II were evaluated. hCA I and hCA II from human erythrocytes were purified by a simple one-step procedure by using Sepharose 4B-L-tyrosine-sulfanilamide affinity column. Our results show that the synthesized compounds inhibited the activity of carbonic anhydrase (CA) I and CA II. Among them, 2b and 2e were found to be the most active (IC50 = 2.12 and 2.52 mu M) for hCA I and hCA II, respectively. | en_US |
| dc.description.sponsorship | Sakarya University - 2012-02-04-033 | en_US |
| dc.identifier.doi | 10.3109/14756366.2012.757603 | |
| dc.identifier.endpage | 136 | en_US |
| dc.identifier.issn | 1475-6366 | |
| dc.identifier.issn | 1475-6374 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopus | 2-s2.0-84893492354 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 132 | en_US |
| dc.identifier.uri | https://doi.org/10.3109/14756366.2012.757603 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/8408 | |
| dc.identifier.volume | 29 | en_US |
| dc.identifier.wos | WOS:000330850300021 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | en_US |
| dc.publisher | Informa Healthcare | en_US |
| dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Carbonic Anhydrase | en_US |
| dc.subject | 1,3-Dicarbonyl | en_US |
| dc.subject | Enzyme Inhibitor | en_US |
| dc.subject | Sulfonamide | en_US |
| dc.title | Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide | en_US |
| dc.type | Article | en_US |
