Inhibition of bovine carbonic anhydrase by new sulfonamide compounds - [2]

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dc.contributor.authorArslan, O.
dc.date.accessioned2025-07-03T21:18:13Z
dc.date.issued2001
dc.departmentBalıkesir Üniversitesi
dc.description.abstractInhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I50 values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma.
dc.identifier.endpage1208
dc.identifier.issn0320-9725
dc.identifier.issue9
dc.identifier.scopus2-s2.0-0035550013
dc.identifier.scopusqualityN/A
dc.identifier.startpage1206
dc.identifier.urihttps://hdl.handle.net/20.500.12462/21255
dc.identifier.volume66
dc.indekslendigikaynakScopus
dc.institutionauthorArslan, O.
dc.language.isoru
dc.relation.ispartofBiokhimiya
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250703
dc.subjectBovine carbonic anhydrase
dc.subjectInhibition
dc.subjectSulfonamides
dc.titleInhibition of bovine carbonic anhydrase by new sulfonamide compounds - [2]
dc.typeArticle

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