Comparison of the role of endocan with other laboratory tests in diagnosis of acute and perforated appendicitis in children

Abstract

Objective: In this study, we aimed to determine the role and efficacy of endocan and other routine laboratory tests to diagnose of acute appendicitis (AA) and determining perforation.

Methods: One hundred patients under the age of 16 who were diagnosed appendicitis were included the study. The patients were divided into two groups as acute and perforated appendicitis. Complete blood count, C-reactive protein (CRP) and endocan values were evaluated on admission and on postoperative 48th hour. Obtained endocan samples and concomitantly obtained CRP, white blood cell (WBC) count, and neutrophil lymphocyte ratio (NLR) parameters were compared preoperatively and postoperatively in terms of perforated and non-perforated (acute) appendicitis.

Results: In this study, 74.2% of the patients were acute and 25.8% were perforated. In both groups, more than half of the patients had an endocan value of less than 50 ng/mL. Specificity and sensitivity of endocan were lower than other inflammation markers to determine AA and perforation. It was shown that the combined evaluation of CRP and NLR values of <9 and <15 respectively, were the best data to diagnose AA and perforation.

Conclusion: The efficacy of endocan was significantly lower than the other routine laboratory markers to determine AA and perforation. It seems more beneficial to use CRP and NLR together to detect infection during early and late period.