The effect of sodium tetraborate on antioxidant enzymes

Abstract

Antioxidant enzymes have main role in the defense of mamma-lian blood. Experimental investigations have repeatedly shownthat erythrocytes are particularly sensitive to oxidative stres. Forthis purpose, thein vitrobiochemical effects of sodium tetraboraton the human blood was investigated in this study. We observedenzyme activities of erythrocyte superoxide dismutase, catalase,glutathione reductase, glutathione s-transferase, glutathione per-oxidase, glucose-6-phosphate dehydrogenase and also the effectof sodium tetraborat on antioxidant enzymes by spectrophoto-metrically. All the heparinized blood samples were taken from 10healthy people between 25 and 35 who were not exposed to anytoxic agents and did not smoke or drink. In this study bloodsamples were exposed to various doses (2, 4, 8, 17, 33 ppm) ofsodium tetraboratin vitroconditions. In conclusion, the resultssuggested sodium tetraborat had shown neither inhibition noractivation effect on antioxidant enzyme activities.