Significance of pPTT-TAPSE and mortality prediction for acute pulmonary thromboembolism in emergency department

Abstract

Aim: TAPSE and pPTT are new echocardiographic parameters recommended in the evaluation of right ventricular function. Examine the echocardiographic parameters of patients diagnosed with acute pulmonary thromboembolism and determine the predictive of mortality.

Materials and Methods: The study was prospectively. Patients diagnosed with pulmonary thromboembolism (PTE) in the emergency department between 06.12.2019-31.05.2020 were included [86 patients (42 case - 44 control)] in the study.

Results: pPTT mean scores of the case and control groups were 91.88 ms and 127,09 ms ( p<0.001). Also, the TAPSE mean scores were 1.76 mm and 2.60 mm for the case and control groups (p<0.001). In terms of sPESI, eight patients (19%) were determined to be at low risk in the case group. On the other hand, of the 34 patients (81%) in the case group determined to be at high risk, In the first 30 days after diagnosis, mortality developed in two patients (4.7%) in the case group. In the control group, the sPESI score of all participants was determined as low risk and no mortality developed (p<0.001). pPTT parameter was observed to be not at statistically significant levels to determine the predictive of mortality [area under the curve (AUC): 0.194, p=0.07]. TAPSE parameter was observed to reach statistically significant levels of distinctive markers to determine the predictive of mortality (AUC: 0.171, p=0.05).

Conclusion: We recommend the determination of pPTT and TAPSE with acute PTE patients in emergency departments to predict mortality indicators and pulmonary pressure changes in the early period.