Predictive Value of Nesfatin-1, Galectin-3, Ghrelin, and Leptin Expressions in Patients with Metabolic Syndrome who Underwent Coronary Artery Bypass Graft (CABG) Surgery

Abstract

Objective: This study aims to investigate the expression of Nesfatin-1, Galectin-3, Ghrelin, and Leptin in mediastinal adipose tissue and their relationship with postoperative complications in patients with and without metabolic syndrome who underwent on-pump coronary artery bypass graft (CABG) surgery. Method: Fifty patients who underwent CABG surgery and who were in sinus rhythm were included in the study. The patients were divided into two groups according to whether they had metabolic syndrome or not. All patients’ age, gender, weight, height, postoperative intensive care unit length of stay, total hospital stay, and post-operative complications (Low cardiac output synd. Inotropy-IABP requirement, insulin-dependent diabetes mellitus, arrhythmia, kidney failure, respiratory failure) were recorded. In the histopathological evaluation, the expression density of Nesfatin-1, Galectin-3, Ghrelin, and Leptin in the the adipose tissue samples were mainly examined. Results: There was no statistically significant difference between the expression of Galectin-3, Ghrelin, and Leptin with post-operative complications, length of stay in the intensive care unit, and body mass index in patients with and without metabolic syndrome. However, there is a significant difference between Nesfatin-1 expression and the risk of postoperative complications, length of stay in intensive care unit and metabolic syndrome (respectively p=0.026, p=0.030, p=0.047). Conclusion: Nesfatin-1 plays a role in glucose homeostasis as a negative regulator of glucose levels. In this study, it is thought that patients with low body mass index and high Nefsatin-1 expression may have a better postoperative clinical course.