The effects of two different antihipertansive drugs as beta blockers-adrenergic receptor antagonists on hca1 and hca2 isozymes in obstructive sleep apnea patients and control group

Abstract

The catalytic function of the enzyme carbonic anhydrase (CA) plays a fundamental role in carbon dioxide (CO2), proton (H+), and bicarbonate (HCO3 ) homeostasis. A specific role of CA in respiration and ventilatory control is suggested by the presence of various CA isoforms in various tissues [1]. Carbonic anhydrase (CA) activity increased with apnea-hypopnea index and related nocturnal hypoxemia measures in patients with obstructive sleep apnea (OSA) [2].