Evaluation of C-Reactive Protein, Albumin, Neopterin, Urokinase Type Plasminogen Activator Receptor and Leukocyte Levels as Prognostic Parameters in Dogs with Parvoviral Enteritis

Abstract

The aim of this study was to determine the changes in C-reactive protein (CRP), albumin, neopterin (Np), urokinase type plasminogen activator receptor (uPAR) and leukocyte levels in dogs with parvoviral enteritis and to show the prognostic importance of these. In the study, a total of 48 dogs, 40 with parvoviral enteritis and 8 were healthy, were used. The dogs with parvoviral enteritis were divided into two subgroups, non-surviving (n=12) and surviving (n=28). The non-surviving dogs with parvoviral enteritis in the study had significantly (p<0.05) lower leukocyte levels than the control group and the surviving dogs with parvoviral enteritis. Serum albumin concentrations of non-surviving dogs with parvoviral enteritis were also significantly (p<0.05) lower than the control group. On the contrary, the CRP levels of the non-surviving and surviving dogs with parvoviral enteritis were significantly (p<0.05) higher than the control group. There was also no statistically significant difference between the groups in terms of Np and uPAR levels. The cut-off values of leukocyte, CRP and albumin were $4.5×10^{9}L$, 120.50 mg/L and 2.28 g/dL, respectively. As a result, it can be stated that decreased leukocyte and albumin levels and increased CRP levels in dogs with parvoviral enteritis may be an indicator of poor prognosis. It was also determined that serum Np and uPAR levels in dogs with parvoviral enteritis do not have any prognostic importance.