Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives
| dc.authorid | 0000-0001-7092-8857 | en_US |
| dc.contributor.author | Karataş, Mert Olgun | |
| dc.contributor.author | Alıcı, Bülent | |
| dc.contributor.author | Çakır, Ümit | |
| dc.contributor.author | Çetinkaya, Engin | |
| dc.contributor.author | Demir, Dudu | |
| dc.contributor.author | Ergün, Adem | |
| dc.contributor.author | Gençer, Nahit | |
| dc.contributor.author | Arslan, Oktay | |
| dc.date.accessioned | 2019-11-01T11:19:00Z | |
| dc.date.available | 2019-11-01T11:19:00Z | |
| dc.date.issued | 2013 | en_US |
| dc.department | Fakülteler, Fen-Edebiyat Fakültesi, Kimya Bölümü | en_US |
| dc.department | Rektörlüğe Bağlı Bölümler, Araştırma ve Uygulama Merkezleri, Bilim ve Teknoloji Uygulama ve Araştırma Merkezi | en_US |
| dc.description | Çakır, Ümit (Balikesir Author) | en_US |
| dc.description.abstract | A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II from human erythrocytes were purified by a simple one step procedure by using Sepharose 4B-L-tyrosine-sulphanilamide affinity column. The result showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Among them, 3g and 3j were found to be most active (IC50 = 22.09 mu M and 20.33 mu M) for hCA I and hCA II, respectively. | en_US |
| dc.description.sponsorship | Inonu University - 2010/31 | en_US |
| dc.identifier.doi | 10.3109/14756366.2012.677838 | |
| dc.identifier.endpage | 304 | en_US |
| dc.identifier.issn | 1475-6366 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopus | 2-s2.0-84889677128 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 299 | en_US |
| dc.identifier.uri | https://doi.org/10.3109/14756366.2012.677838 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/9471 | |
| dc.identifier.volume | 28 | en_US |
| dc.identifier.wos | WOS:000314531000009 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | en_US |
| dc.publisher | Informa Healthcare | en_US |
| dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Carbonic Anhydrase | en_US |
| dc.subject | Coumarin | en_US |
| dc.subject | Benzimidazolium | en_US |
| dc.subject | Inhibition | en_US |
| dc.title | Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives | en_US |
| dc.type | Article | en_US |
