Synthesis of new sulfonamide inhibitors of carbonic anhydrase

Abstract

Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxyl]ethane (SBAM), 1, 2-bis[(4-sulfonamidobenzoate)ethoxy]ethane,1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1, 2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.