CA XII expression study in HT 29 colon carcinoma cell line upon cytokine TNF-alpha and TGF-beta stimulations

Abstract

Introduction: Carbonic anhydrases (CA, EC 4.2.1.1) are a family of metalloenzymes catalyzing the hydration of CO2 to bicarbonate and a proton. a-Cas is involved in essential cellular functions such as pH regulation, respiration, gluconeogenesis, lipogenesis, ureagenesis, and tumor progression. So far, 15 catalytically active carbonic anhydrase isozymes are described in mammals. hCA XII is one of the transmembrane human carbonic anhydrase isoforms. hCA XII is present in many normal tissues and over-expressed in some tumors