Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release

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dc.authorid0000-0003-0914-1128en_US
dc.authorid0000-0002-5913-8333en_US
dc.authorid0000-0002-9453-4462en_US
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTamahkar, Emel
dc.contributor.authorİdil, Neslihan
dc.contributor.authorSuloğlu, Aysun Kılıç
dc.contributor.authorPerçin, Işık
dc.date.accessioned2021-03-05T06:51:40Z
dc.date.available2021-03-05T06:51:40Z
dc.date.issued2020en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Gıda Mühendisliği Bölümüen_US
dc.descriptionHitit University Scientific and Technical Application and Research Centeren_US
dc.description.abstractThe development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.en_US
dc.identifier.doi10.1002/ddr.2174
dc.identifier.endpage10en_US
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.scopus2-s2.0-85091851085
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1002/ddr.2174
dc.identifier.urihttps://hdl.handle.net/20.500.12462/11139
dc.identifier.volumeEarly Access: OCT 2020en_US
dc.identifier.wosWOS:000574568700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDrug Development Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAntibiotic Releaseen_US
dc.subjectChitosan-Gelatin Hydrogelsen_US
dc.subjectHyaluronic Acid Nanoparticles Embeddingen_US
dc.titleEvaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic releaseen_US
dc.typeArticleen_US

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