Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method

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dc.authorid0000-0002-8446-1116en_US
dc.contributor.authorYılmaz, Begümhan
dc.contributor.authorDoğan, Serap
dc.contributor.authorKasımoğulları, Serap Çelikler
dc.date.accessioned2019-08-06T06:37:48Z
dc.date.available2019-08-06T06:37:48Z
dc.date.issued2018en_US
dc.departmentFakülteler, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.descriptionYılmaz, Begümhan (Balikesir Author)en_US
dc.description.abstractThe aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity.en_US
dc.description.sponsorshipScientific Research Projects Commission of Balikesir University BAP 15/120 Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.identifier.doi10.1080/00914037.2017.1331349
dc.identifier.endpage360en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85027382923
dc.identifier.scopusqualityQ1
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2017.1331349
dc.identifier.urihttps://hdl.handle.net/20.500.12462/5845
dc.identifier.volume67en_US
dc.identifier.wosWOS:000424789900003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectHemocompatibilityen_US
dc.subjectNanocompositeen_US
dc.subjectNanohydroxyapatiteen_US
dc.subjectPMMAen_US
dc.titleHemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending methoden_US
dc.typeArticleen_US

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