Histopathological evaluation of endometrial sampling in different age groups - 1374 cases

Abstract

The aim of this study was to evaluate the relationship between histopathological results and endometrial sampling and to identify specific pathologies in different age groups. The histopathological results of 1374 cases registered in our pathology archives, in whom endometrial sampling was performed in our hospital for various reasons between 2013 and 2014 were evaluated. Biopsy indications included menometrorrhagia (80.5%), postmenopausal bleeding (6.8%), myoma uteri (1.7%), cervical polyp (2.4%), infertility (0.2%), and hyperplasia/malignancy (8.4%). Histopathological diagnoses in order of frequency included endometrial polyp (37.2%), proliferation/secretion/menstrual phase (29.3%), irregular proliferative endometrium (8.4%), insufficient biopsy material (8.4%), endometritis (5.8%), stroma-glandular breakdown (4.2%), endometrial hyperplasia (4%), iatrogenic changes (1.4%), atrophic endometrium (1.2%), and malignancy (0.1%). Endometrial polyps were detected in 14 of 33 patients with cervical polyps In endometrial samplings performed in patients in whom hysterectomy was planned due to myoma uteri, the most frequent diagnosis was a normal cyclic pattern (50%). In conclusion, in the present study, the most frequent biopsy indications of endometrial sampling were menometrorrhagia, and the most frequent histopathological diagnosis was endometrial polyp. Endometrial polyp was also identified concomitantly in endometrial sampling of 14 out of 33 patients with cervical polyps. Thus, we concluded that in patients with an initial diagnosis of cervical polyp, the endometrium should also be evaluated.

Bu çalışmanın amacı, endometriyal örneklemin histopatolojik sonuçlarla ilişkisini değerlendirmek ve farklı yaş gruplarındaki spesifik patolojileri tanımlamaktır. Hastanemizde 2013-2014 yılları arasında çeşitli nedenlerle endometrial örnekleme yapılan patoloji arşivlerinde yer alan 1374 olgunun histopatolojik sonuçları değerlendirildi. Biyopsi endikasyonları; menometrorrhagia (%80,5), postmenopozal kanama (%6,8), myoma uteri (%1,7), servikal polip (%2,4), infertilite (%0,2) ve hiperplazi-malignite (%8.4) idi. Histopatolojik tanılar endometrial polip (%37,2), proliferasyon / sekresyon / menstrüel faz (%29,3), düzensiz çoğalma endometriyumu (%8.4), yetersiz biyopsi materyali (%8.4), endometrit (%5.8) (% 4.2), iyatrojenik değişiklikler (%1.4), atrofik endometrium (%1.2), malignite (%0.1) ve endometriyum hiperplazisi (%4) izlendi. Servikal polip bulunan hastalardaki 33 endometriyal küretajın 14’ünde endometrial polip tespit edildi. Myoma uteri nedeniyle histerektomi planlanan olgularda yapılan endometriyal örneklemelerde en sık görülen normal siklik paterndi (%50) idi. Çalışmamızda en sık görülen tanı endometrial polip olarak tanımlandı. Servikal polipin ön tanısı konan vakalarda endometriyumun da değerlendirilmesi gerektiği sonucuna varıldı.