Inhibition studies on mutant Phe91Asn human carbonic anhydrase I (HCA I) gene

Abstract

Carbonic anhydrases (CAs; carbonate dehydratases EC 4.2.1.1) are ubiquitous metalloenzymes present in prokaryotes and eukaryotes that and encoded by four evolutionarily different gene families. In mammals, 15 a-CA isozymes or CA-related proteins have been described, with different catalytic activity, subcellular localization and tissue distribution. CAI is a member of a-CA family and situated on the long arm of chromosome 8. It presents in erythrocytes, colon epithelium, lens of eye and corneal epithelium and the most abundant protein after hemoglobin in erythrocytes.