Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats

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dc.authorid0000-0001-5914-7750en_US
dc.authorid0000-0002-4827-804Xen_US
dc.authorid0000-0002-1769-2512en_US
dc.contributor.authorYıldırım, Hatice
dc.contributor.authorDaşkan, Burcu Efe
dc.contributor.authorAksöz, Elif
dc.contributor.authorSen, Fazilet
dc.contributor.authorÇelebi, Murat
dc.date.accessioned2024-05-08T10:21:21Z
dc.date.available2024-05-08T10:21:21Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentFakülteler, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.departmentMeslek Yüksekokulları, Savaştepe Meslek Yüksekokuluen_US
dc.description.abstractChanges in gene expression with aging are associated with a decline in physical and cognitive abilities. Here, we investigated the changes in mRNA and protein expression of TSPAN8 and SERT in the different parts of the brain for different age group rats. Our protein analysis revealed that aging mainly triggers SERT gene expression in the cerebellum and hippocampus, showing that an increase in mRNA expression correlates with protein expression. For TSPAN8, age-dependent protein increase was observed in the hippocampus and highest expression was observed for adult and middle-aged rats.en_US
dc.description.sponsorshipBalikesir University 2022/070en_US
dc.identifier.doi10.1016/j.gene.2023.147706
dc.identifier.endpage7en_US
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.issue885en_US
dc.identifier.scopus2-s2.0-85168431709
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.gene.2023.147706
dc.identifier.urihttps://hdl.handle.net/20.500.12462/14645
dc.identifier.wosWOS:001061273600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectSERTen_US
dc.subjectTSPAN8en_US
dc.subjectRaten_US
dc.subjectBrainen_US
dc.titleRegional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged ratsen_US
dc.typeArticleen_US

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