In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)
| dc.authorid | 0000-0001-7092-8857 | en_US |
| dc.contributor.author | Gökce, Başak | |
| dc.contributor.author | Gencer, Nahit | |
| dc.contributor.author | Arslan, Oktay | |
| dc.contributor.author | Karataş, Mert Olgun | |
| dc.contributor.author | Alıcı, Bülent | |
| dc.date.accessioned | 2019-10-17T11:06:59Z | |
| dc.date.available | 2019-10-17T11:06:59Z | |
| dc.date.issued | 2016 | en_US |
| dc.department | Fakülteler, Fen-Edebiyat Fakültesi, Kimya Bölümü | en_US |
| dc.description | Gençer, Nahit (Balikesir Author) | en_US |
| dc.description.abstract | Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro effect of some hydroxy and dihydroxy ionic coumarin derivatives (1-20) on purified PON1 activity was investigated. Among these compounds, derivatives 11-20 are water soluble. In investigated compounds, compounds 6 and 13 were found the most active (IC50 = 35 and 34 mu M) for PON1, respectively. The present study has demonstrated that PON1 activity is very highly sensitive to studied coumarin derivatives. | en_US |
| dc.description.sponsorship | Balikesir University Research project 2014/54 | en_US |
| dc.identifier.doi | 10.3109/14756366.2015.1043297 | |
| dc.identifier.endpage | 537 | en_US |
| dc.identifier.issn | 1475-6366 | |
| dc.identifier.issn | 1475-6374 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopus | 2-s2.0-84964618024 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 534 | en_US |
| dc.identifier.uri | https://doi.org/ 10.3109/14756366.2015.1043297 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/8441 | |
| dc.identifier.volume | 31 | en_US |
| dc.identifier.wos | WOS:000379783200003 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor & Francis Inc | en_US |
| dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Coumarin Derivatives | en_US |
| dc.subject | In Vitro İnhibition | en_US |
| dc.subject | Paraoxonase | en_US |
| dc.title | In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1) | en_US |
| dc.type | Article | en_US |
