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dc.contributor.authorErzengin, Mahmut
dc.contributor.authorBilen, Çiğdem
dc.contributor.authorErgün, Adem
dc.contributor.authorGençer, Nahit
dc.date.accessioned2019-10-17T11:03:53Z
dc.date.available2019-10-17T11:03:53Z
dc.date.issued2014en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.urihttps://doi.org/10.3109/13813455.2013.863359
dc.identifier.urihttps://hdl.handle.net/20.500.12462/8394
dc.descriptionBilen, Çiğdem (Balikesir Author)en_US
dc.description.abstractThe antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly to their target through intermolecular interactions. That's why enzyme inhibition studies are an important issue for drug design and biochemical applications. In this study, in vitro inhibition effect of some antipsychotic drugs on the purified carbonic anhydrase (CA) I and II isoenzymes were investigated by using CO2 as a substrate. CA I and II were purified from human erythrocytes by a simple one step procedure using Sepharose 4B-L-tyrosine-sulfonamide affinity column. The results showed that all the drugs inhibited the cytosolic carbonic anhydrases enzyme activity in a concentration-dependent fashion. Among the studied drugs, aripiprazole and pramipexole were found to be the most active one for hCA I (IC50: 3.64 and 5.37 mu M) and hCA II (IC50: 4.16 and 4.81 mu M) activity, respectively.en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/13813455.2013.863359en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntipsychotic Drugsen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectInhibitionen_US
dc.subjectPurificationen_US
dc.titleAntipsychotic agents screened as human carbonic anhydrase I and II inhibitorsen_US
dc.typearticleen_US
dc.relation.journalArchives of Physiology and Biochemistryen_US
dc.contributor.departmentFen Edebiyat Fakültesien_US
dc.contributor.authorID0000-0001-7092-8857en_US
dc.identifier.volume120en_US
dc.identifier.issue1en_US
dc.identifier.startpage29en_US
dc.identifier.endpage33en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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