Güncel Gönderiler: Moleküler Biyoloji ve Genetik Bölümü
Toplam kayıt 114, listelenen: 41-60
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Development and characterization of superparamagnetic nanomaterial to determine its potential application in removing the bitterness of table olives
(MYU, 2020)The aim of this study is to develop stable superparamagnetic iron oxide nanoparticles (SPIONs) for the immobilization of beta-glucosidase. The goal is to figure out the possibility of applying immobilization techniques in ... -
Preparing and optimizing a newly affinity gel for purification of carbonic anhydrase isoenzymes
(Parlar Scientific Publications (P S P), 2020)Human carbonic anhydrase isozymes have been purified from the hemolysate, directly by using the original affinity gel in chemical structure of Sepharose 4B-L-tyrosine- sulfathiazole. Different solution buffers were used ... -
Inhibitory effects of anticancer drugs on cytosolic carbonic anhydrase isozymes
(Parlar Scientific Publications (P S P), 2020)Anticancer drugs are widely used cancer treatment. Human carbonic anhydrase I and II were shown widely distribution with erythrocytes so it is important to understand how effect is anticancer drugs these isozymes. In this ... -
The chemical components, antioxidant and anticancer activities of ziziphus jujube extracts from Turkey
(Agrimedia GMBH, 2020)The bioactive components which are nutritionally and medically important of jujube fruit have been shown to vary with growing conditions. In this study, the cytotoxic effect of Ziziphus jujube fruit, which is in two different ... -
Immobilization xanthine oxidase on interdigitated electrode for biosensor investigation
(Parlar Scientific Publications (P S P), 2020)Biosensors can be developed using different biological materials and immobilization technologies. Interest in immobilization techniques has increased because they allow for the improvement of some stability characteristics ... -
Upregulation of PSMD4 gene by hypoxia in prostate cancer cells
(Tubitak Scientific & Technical Research Council Turkey,, 2020)Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. ... -
Inhibition effect of some chemical on lactoperoxidase and covalently immobilized on a biocomposite for biosensor
(Parlar Scientific Publications (P S P), 2020)Lactoperoxidase was purified from bovine milk using ammonium sulfate precipitation and affinity chromatography. The greatest purification fold for lactoperoxidase has been obtained as 1302.65 folds with 24.95 % yields. The ... -
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
Molecular cloning and biochemical characterization of a Tau class glutathione S-transferase from Pinus brutia Ten
(Springer Heidelberg, 2020)Key message A new Tau class GST gene was cloned from Pinus brutia Ten. cDNA sequence was analysed for conserved sequences. Substrate specificity, optimum pH, and temperature values of the recombinant PbGST Tau enzyme were ... -
Evaluation of Azadirachtin on Arthrospira plantensis Gomont growth parameters and antioxidant enzymes
(EDP Sciences S A, 2020)To understand the effects of contamination of insecticides onphototrophs, and to determine the responses of these organisms against these chemicals are extremely important in understanding how the ecosystem is affected. ... -
Synthesis, characterization, and their some chemical and biological properties of PVA/PAA/nPS hydrogel nanocomposites: Hydrogel and wound dressing
(Sage Publications, 2020)The nanocomposite hydrogels were prepared by dispersing of the nanopomegranate seed particles into poly(vinyl alcohol)/poly(acrylic acid) blend matrix in an aqueous medium by the solvent casting method. These hydrogels ... -
TNF-alpha induces URG-4/URGCP gene expression in hepatoma cells through starvation dependent manner
(Springer/Plenum Publishers, 2020)URG-4/URGCP is a gene that may be associated with the onset of tumorigenesis and cell cycle regulation. In the literature, there is no study about inflammatory cytokine-mediated URG-4/URGCP regulation. In this study, the ... -
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
(Springer Wien, 2020)Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ... -
The effects on antioxidant enzymes of PMMA/hydroxyapatite nanocomposites/composites
(Elsevier Sci Inc, 2020)In this study, polymer-ceramic nanocomposites and/or composites were prepared by solution removal method using poly(methylmethacrylat) (PMMA) and nano-hydroxyapatite (nHA). They were characterized using X-ray diffraction ... -
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation
(Academic Press Inc Elsevier Science, 2020)In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well ... -
Carbonic anhydrase III is a new target of HIF1 alpha in prostate cancer model
(Elsevier, 2020)Carbonic Anhydrase III (CAIII) belongs to a member of the alpha Carbonic Anhydrase (CA) family. Although some CA members are strongly up-regulated by HIF1-alpha, it is not known about the transcriptional regulation of CAIII ... -
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ... -
Synthesis, characterization and some biological properties of Pva/Pvp/Pn hydrogel nanocomposites: Antibacterial and biocompatibility
(Sciendo, 2019)In this study, it was aimed to synthesize hydrogel based antibacterial, biocompatible and non-toxic wound dressing materials by solvent removal method usingpoly(vinylalcohol) (PVA), poly(vinylpyrolidone) (PVP) and nano ... -
TGF-beta downregulates CAIII expression via MAPK and PI3K signaling pathways in colon carcinoma and osteosarcoma cells
(Inst Bioloska Istrazivanja Sinisa Stankovic, 2019)Identification of cancer-associated genes is critical for developing effective treatments of colorectal cancer (CRC). A limited number of studies have examined the mechanisms and genes underlying CRC. Abnormal transforming ... -
Synthesis, characterization and biological properties of intercalated kaolinite nanoclays: intercalation and biocompatibility
(De Gruyter Poland Sp Zoo, 2019)The aims of the present study were to synthesize the intercalated kaolinite samples with dimethylsulfoxide (DMSO), glutamic acid (GA), succinimide (SIM), cetylpyridiniumchloride (CPC), and hexadecyltrimethylammoniumchloride ...
