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dc.contributor.authorKızılay, Zahir
dc.contributor.authorErken, Haydar Ali
dc.contributor.authorÇetin, Nesibe Kahraman
dc.contributor.authorAktaş, Serdar
dc.contributor.authorAbas, Burçin İrem
dc.contributor.authorYılmaz, Ali
dc.date.accessioned2019-10-17T06:36:08Z
dc.date.available2019-10-17T06:36:08Z
dc.date.issued2016en_US
dc.identifier.issn1673-5374
dc.identifier.issn1876-7958
dc.identifier.urihttps://doi.org/10.4103/1673-5374.193247
dc.identifier.urihttps://hdl.handle.net/20.500.12462/7324
dc.descriptionErken, Haydar Ali (Balikesir Author)en_US
dc.description.abstractThe aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups (n = 7): control (C), boric acid (BA), sciatic nerve injury (I), and sciatic nerve injury + boric acid treatment (BAI). Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury (by gavage at 0, 24, 48 and 72 hours) but no injury was made in the group BA. In vivo electrophysiological tests were performed at the end of the day 4 and sciatic nerve tissue samples were taken for histopathological examination. The amplitude of compound action potential, the nerve conduction velocity and the number of axons were significantly lower and the myelin structure was found to be broken in group I compared with those in groups C and BA. However, the amplitude of the compound action potential, the nerve conduction velocity and the number of axons were significantly greater in group BAI than in group I. Moreover, myelin injury was significantly milder and the intensity of nuclear factor kappa B immunostaining was significantly weaker in group BAI than in group I. The results of this study show that administration of boric acid at 100 mg/kg after sciatic nerve injury in rats markedly reduces myelin and axonal injury and improves the electrophysiological function of injured sciatic nerve possibly through alleviating oxidative stress reactions.en_US
dc.language.isoengen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.isversionof10.4103/1673-5374.193247en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve Regenerationen_US
dc.subjectPeripheral Nerve Injuryen_US
dc.subjectSciatic Nerveen_US
dc.subjectBoric Aciden_US
dc.subjectNerve Conduction Velocityen_US
dc.subjectAxonen_US
dc.subjectElectrophysiologyen_US
dc.subjectNeural Regenerationen_US
dc.titleBoric acid reduces axonal and myelin damage in experimental sciatic nerve injuryen_US
dc.typearticleen_US
dc.relation.journalNeural Regeneration Researchen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume11en_US
dc.identifier.issue10en_US
dc.identifier.startpage1660en_US
dc.identifier.endpage1665en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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