| dc.contributor.author | Sönmez, Fatih | |
| dc.contributor.author | Sevmezler, Sedat | |
| dc.contributor.author | Atahan, Alparslan | |
| dc.contributor.author | Ceylan, Mustafa | |
| dc.contributor.author | Demir, Dudu | |
| dc.contributor.author | Gençer, Nahit | |
| dc.contributor.author | Arslan, Oktay | |
| dc.contributor.author | Küçükislamoğlu, Mustafa | |
| dc.date.accessioned | 2019-10-16T11:25:16Z | |
| dc.date.available | 2019-10-16T11:25:16Z | |
| dc.date.issued | 2011 | en_US |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | https://doi.org/ 10.1016/j.bmcl.2011.09.130 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/7076 | |
| dc.description | Demir, Dudu (Balıkesir Author) | en_US |
| dc.description.abstract | A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
| dc.relation.isversionof | 10.1016/j.bmcl.2011.09.130 | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Chalcones | en_US |
| dc.subject | Tyrosinase InhibitorI | en_US |
| dc.title | Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Bioorganic & Medicinal Chemistry Letters | en_US |
| dc.contributor.department | Fen Edebiyat Fakültesi | en_US |
| dc.contributor.authorID | 0000-0001-7092-8857 | en_US |
| dc.identifier.volume | 21 | en_US |
| dc.identifier.issue | 24 | en_US |
| dc.identifier.startpage | 7479 | en_US |
| dc.identifier.endpage | 7482 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
