Güncel Gönderiler: Temel Tıp Bilimleri-Makale Koleksiyonu
Toplam kayıt 279, listelenen: 21-40
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Preconditioning of human umbilical cord mesenchymal stem cells with a histone deacetylase inhibitor: Valproic acid
(Galenos Publishing House, 2024)Background: Mesenchymal stem cells (MSCs) play a key role in regenerative medicine due to their capacity to differentiate into multiple cell lines, regulate the immune system, and exert paracrine effects. The therapeutic ... -
Vegan yaşam tarzını benimseyen bireylerin karşılaştığı psikososyal risk faktörleri
(Balıkesir Üniversitesi Sosyal Bilimler Enstitüsü, 2024)İnsanlar etik, ekolojik, dini veya sağlık temelli motivasyonlar sebebiyle vejetaryen veya vegan beslenmeye geçiş yapmaktadır. Vejetaryen beslenme tarzının kendi içerisinde birçok çeşidi bulunmaktadır. Fakat bu diyet ... -
Ticari doğal aktif bileşenlerin sıtma tedavisindeki etkinliğinin araştırılması
(Türk Mikrobiyoloji Cemiyeti, 2024)Amaç: Bu çalışmada, çeşitli biyolojik aktiviteleri yanında, güçlü antimikrobiyal etkinlikleri gösterilmiş olan kafeik asit, oleik asit ve oleuropin’in in vitro sitotoksik aktivitesi ve in vivo antimalaryal etkinliğinin ... -
Discoidin domain receptor 1 as a promising biomarker for high-grade gliomas
(Wolters Kluwer Medknow Publications, 2023)Background: Two fundamental challenges in the current therapeutic approach for central nervous system tumors are the tumor heterogeneity and the absence of specific treatments and biomarkers that selectively target the ... -
Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p. R450C) in the RHOT1 gene encoding Miro1
(Elsevier, 2023)Fibroblasts from two Parkinson's disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in the RHOT1 gene, were converted into induced pluripotent stem ... -
Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats
(C M B Assoc, 2023)The basic objective of this study was to examine the possible effects of treadmill exercise on obesity-related sexual behavior disorder in obese male rats and the role of kisspeptin in this effect. The rats were separated ... -
Service quality, outpatient satisfaction and loyalty in community pharmacies in Turkey: A structural equation modeling approach
(Elsevier, 2023)Background: The sustainability of community pharmacy services is dependent on service quality, patient satisfaction, and patient loyalty. While community pharmacies are perceived as medical units in terms of drug dispensing, ... -
TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats
(C M B Assoc, 2023)Excessive high fructose corn syrup (HFCS) consumption is known to cause oxidative stress, which induces transient receptor potential melastatin type 2 (TRPM2) channel gating. Oxidative stress-induced TRPM2 gating is suggested ... -
Monensin, an antibiotic isolated from streptomyces cinnamonensis, regulates human neuroblastoma cell proliferation via the PI3K/AKT signaling pathway and acts synergistically with rapamycin
(MDPI, 2023)Neuroblastoma is the most common extracranial childhood tumor and accounts for approximately 15% of pediatric cancer-related deaths. Further studies are needed to identify potential therapeutic targets for neuroblastoma. ... -
The role of decoy receptor 3 in inflammation and atherosclerosis in patients with chronic kidney disease and renal transplant patients
(Soc Espanola Nefrologia Dr Rafael Matesanz, 2023)Introduction: The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated ... -
Effects of Romanian student's awareness and needs regarding plastic waste management
(MDPI, 2023)The purpose of this study is to examine the effects of needs and awareness of university students on their environmental behaviour. With this purpose the data was collected from 537 students from the University of Cluj ... -
Hyperarc Vmat and Vmat planning for stereotactic radiosurgery in multiple brain metastases
(Elsevier, 2023)Automated treatment planning systems are available for linear accelerator (LINAC) based single and more isocenter multitarget stereotactic radiosurgery (SRS) of brain metastases. HyperArc Volumetric Modulated Arc Therapy ... -
AGR2 gene expression in glioblastoma: A novel molecular potential target for diagnosis and treatment
(Turkish Neurosurgical Society, 2023)AIM: To assess anterior gradient protein 2 (AGR2) gene expression in patients with human glioblastoma (GBM) in comparison to levels in healthy brain tissues. MATERIAL and METHODS: We evaluated the expression levels of AGR2 ... -
Effects of chronically exogenous oxytocin on ovary and uterus: A comparison of intraperitoneal and intranasal administration
(Elsevier, 2023)Oxytocin (OT) has been studied as a therapeutic neuropeptide in various diseases, but its effect on the ovary and uterus is not fully known. This study investigates the effects of intranasal and intraperitoneal OT ... -
Erianin as a promising novel agent in the treatment of neuroblastoma: The anti-cancer effects and underlying molecular mechanisms
(Bentham Science Publishers, 2023)Background: Erianin is an active dibenzyl compound isolated from Dendrobium officinale and Dendrobium chrysotoxum and there are very few studies on molecular mechanisms and drug targets of erianin. In addition, there is ... -
Investigation of the anticancer mechanism of monensin via apoptosis-related factors in SH-SY5Y neuroblastoma cells
(Wiley, 2023)Monensin is an ionophore antibiotic that inhibits the growth of cancer cells. The aim of this study was to investigate the apoptosis-mediated anticarcinogenic effects of monensin in SH-SY5Y neuroblastoma cells. The effects ... -
Modulation of melatonin receptors regulates reproductive physiology: The impact of agomelatine on the estrus cycle, gestation, offspring, and uterine contractions in rats
(Acad Sciences Czech Republic, 2023)Agomelatine is a pharmaceutical compound that functions as an agonist for melatonin receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action is integral to the regulation of diverse ... -
A cross-cultural analysis for plastic waste perception of students from Romania and Turkey
(MDPI, 2023)The article brings to attention a cross cultural model related to the perception of students in relation to the current problem of plastic waste. To create the model, a questionnaire was applied online in two countries at ... -
Treadmill exercise improves behavioral and neurobiological alterations in restraint-stressed rats
(Springer Nature, 2023)Stress is a state that is known to impact an organism's physiological and psychological balance as well as the morphology and functionality of certain brain areas. In the present work, chronic restraint stress (CRS) model ... -
Development and validation of liquid chromatography/stable isotope-dilution tandem mass spectrometry method for measurement of dexamethasone, total cortisol and free cortisol in human plasma
(Dokuz Eylul Univ Inst Health Sciences, 2023)Background Cortisol plays a role in the regulation of metabolic homeostasis. Dexamethasone is a powerful synthetic glucocorticoid that acts as an anti-inflammatory and immunosuppressive agent. Plasma free cortisol, which ...
