Perspective chapter: Candida and Candidiasis - recent taxonomic developments, invasion biology, and novel active compounds
Özet
Candida spp. infections are most predominantly caused by Candida albicans,
followed by C. glabrata, C. parapsilosis and C. tropicalis. Candida spp. can cause a wide
range of serious infections. Recent studies indicate that this genus has approximately
200 species. Candidiasis is a fungal infection caused by Candida spp. Sexual reproduction gives eukaryotic organisms some advantages, such as producing adaptable
fertility to changing environments and eliminating harmful mutations. Relationships
between epithelial cells and Candida spp. include responses to medically important
fungal pathogens. Infection by C. albicans, which has significantly high virulence due
to its biofilm formation feature, is rather difficult to manage. Invasive candidiasis is
a serious infection that can affect the blood, brain, eyes, bones, heart or other parts
of the body. Understanding C. albicans invasion kinetics is crucial to controlling
the pathogen’s intrusion into the cells. New and effective antifungal compounds are
needed due to the limited number and competence of antifungal agents. The search
for natural compounds with anti-candidiasis effects continues increasingly.
