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dc.contributor.authorGümüş, Hikmet
dc.contributor.authorIlgın, Rabia
dc.contributor.authorKoç, Başar
dc.contributor.authorYüksel, Oğuz
dc.contributor.authorKızıldağ, Servet
dc.contributor.authorGüvendi, Güven
dc.contributor.authorKarakılıç, Aslı
dc.date.accessioned2023-12-21T13:32:23Z
dc.date.available2023-12-21T13:32:23Z
dc.date.issued2022en_US
dc.identifier.issn0304-3940 / 1872-7972
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2021.136443
dc.identifier.urihttps://hdl.handle.net/20.500.12462/13656
dc.descriptionKarakılıç, Aslı (Balikesir Author)en_US
dc.description.abstractThe positive effects of both ketogenic diet (KD) and regular voluntary exercise on anxiety and depression behavior have been recently reported in rodent animals, but the effects of pairing a KD with exercise on depression and anxiety are unknown. In this study, we aimed to investigate the effects of combination of KD and regular voluntary exercise on anxiety and depression-like behavior in Balb/c mice. We've demostrated that anxiety and depression levels decreased in KD-exercised (KD-Ex) mice. beta-hydroxybutyrate (BHB) levels increased while glucose, insulin levels and LDL/HDL ratio decreased in KD-Ex mice. There was a negative correlation between BHB and the time spent in the closed arms of elevated plus maze (EPM) or the time spent in periphery walls of open field test (OFT) and the immobility time in forced swim test (FST) which all of them are indicators of low depression and anxiety levels. There was a positive correlation between LDL/HDL ratio and the time spent in the closed arms of EPM or the immobility time in FST. The immobility time in FST was positively correlated with insulin while the mobility time in FST was negatively correlated with glucose. In conclusion, these results suggest that decline in anxiety and depression-like behaviors resulted from KD with regular voluntary exercise may be associated with increased BHB levels and decreased LDL/HDL ratio and insulin or glucose levels. Further research is necessary for our understanding of the mechanisms by which pairing a KD with voluntary exercise influences brain and behavior.en_US
dc.description.sponsorship100/2000 YOdKen_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.isversionof10.1016/j.neulet.2021.136443en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectKetogenic Dieten_US
dc.subjectRegular Voluntary Exerciseen_US
dc.subjectAnxiety and Depressionen_US
dc.subjectBeta-Hydroxybutyrateen_US
dc.titleA combination of ketogenic diet and voluntary exercise ameliorates anxiety and depression-like behaviors in Balb/C miceen_US
dc.typearticleen_US
dc.relation.journalNeuroscience Lettersen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0003-1834-0444en_US
dc.contributor.authorID0000-0002-8310-1979en_US
dc.contributor.authorID0000-0001-7671-4868en_US
dc.contributor.authorID0000-0001-7788-4949en_US
dc.identifier.volume770en_US
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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