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dc.contributor.authorAtmaca, Nurgül
dc.contributor.authorAtmaca, Hasan Tarık
dc.date.accessioned2023-09-11T11:19:40Z
dc.date.available2023-09-11T11:19:40Z
dc.date.issued2022en_US
dc.identifier.issn0014-4894 / 1090-2449
dc.identifier.urihttps://doi.org/10.1016/j.exppara.2022.108311
dc.identifier.urihttps://hdl.handle.net/20.500.12462/13347
dc.description.abstractAcute Toxoplasma gondii infections can influence the liver as well as other organs. Many cytokines and proteins play a role in the acute response against infection. Tumor necrosis factor alpha (TNF alpha) is a cytokine that plays a key function in stimulating hepatocytes to produce acute phase proteins. In this study, we investigated TNF alpha levels associated with the levels of macroglobulin, haptoglobin, hemopexin, C-reactive protein (CRP), albumin, serum amyloid alpha protein (SAA), and clusterin, which are acute phase proteins, in serum of mice with T. gondii infection. In the experiment, a total of 24 mice were used; 6 mice constituted the control group and 18 mice were infected with the RH strain. On the 2nd, 4th, and 6th days following the infection, 6 animals were euthanized, and their serums were collected. Compared to the control group, we observed a statistically significant decrease in albumin concentration in the group with T. gondii infection on the 6th day. Also, this group displayed a statistically significant, gradual increase in clusterin levels on the 2nd and 6th days, C-reactive protein levels on the 4th day, haptoglobin levels on the 2nd and 4th days, hemopexin levels on the 2nd day, serum amyloid A levels on the 2nd, 4th, and 6th days, and TNF-α levels on the 2nd, 4th, and 6th days (p < 0.05). TNF-α was strongly positively correlated with CRP, SAA, and clusterin, moderately positively correlated with hemopexin, and strongly negatively correlated with albumin. The increase in CRP, SAA, clusterin, and hemopexin levels on the 2nd day after infection, in parallel with the increase in TNF-α levels, indicates that these proteins can be considered as major acute phase proteins in acute T. gondii infection in mice. The data obtained here may be helpful for the diagnosis of T. gondii infection and for monitoring treatments.en_US
dc.description.sponsorshipKirikkale Universityen_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.isversionof10.1016/j.exppara.2022.108311en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectToxoplasma Gondiien_US
dc.subjectAcute Phase Proteinsen_US
dc.subjectTNF Alphaen_US
dc.subjectMiceen_US
dc.subjectLiveren_US
dc.subjectImmunohistochemistryen_US
dc.titleThe correlation of TNF alpha levels with acute phase proteins in acute Toxoplasma gondii infection in miceen_US
dc.typearticleen_US
dc.relation.journalExperimental Parasitologyen_US
dc.contributor.departmentVeteriner Fakültesien_US
dc.contributor.authorID0000-0001-8379-4114en_US
dc.contributor.authorID0000-0003-3141-8031en_US
dc.identifier.volume239en_US
dc.identifier.issueAugusten_US
dc.identifier.startpage1en_US
dc.identifier.endpage6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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