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dc.contributor.authorAltun, Eren
dc.contributor.authorYıldız, Ayla
dc.contributor.authorÇevik, Celalettin
dc.contributor.authorTuran, Gülay
dc.date.accessioned2020-01-27T13:49:46Z
dc.date.available2020-01-27T13:49:46Z
dc.date.issued2019en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.urihttps://hdl.handle.net/20.500.12462/10620
dc.descriptionAltun, Eren (Balikesir Author)en_US
dc.description.abstractPurpose: To evaluate serum levels of high-sensitivity C-reactive protein (hs-CRP) in chronic gastritis patients to predict Helicobacter pylori (HP) infection, inflammatory activity, and precancerous lesions. Methods: A total of 811 patients with upper gastrointestinal symptoms and histopathological diagnosis of chronic gastritis were enrolled in the study. On endoscopy, five gastric biopsies were taken according to Modified Sydney protocol, which were stained with hematoxylin & eosin and Giemsa Results: HP infection was found in 28.6% of patients, being significantly more common in specimens with acute and chronic inflammatory activity. Mucosal atrophy, intestinal metaplasia, and dysplasia were found in 20.2%, 18.8% and 2.7% of biopsy specimens. Mean hs-CRP was 1.9 +/- 1.6 mg/dl for males and 2.2 +/- 1.9 mg/dl for females. hs-CRP average were significantly higher in patients with severe acute inflammation (p:0.049), in patients with severe chronic inflammation (p:0.015) and in those with HP (p:0.001). The severity of HP infection increased significantly with the increased degree of acute inflammation, chronic inflammation and hs-CRP level (p=0.001 for both). Conclusion: Serum hs-CRP level increases in patients with chronic gastritis, it could be an indicator of severity of acute or chronic mucosal inflammation, and presence of HP infection. Therefore, hs-CRP may aid the diagnosis of chronic gastritis, but it is not associated with precancerous lesions.en_US
dc.language.isoengen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.isversionof10.1590/s0102-865020190030000010en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastritisen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectHelicobacter Pylorien_US
dc.subjectInflammationen_US
dc.titleThe role of high sensitive c-reactive protein and histopathological evaluation in chronic gastritis patients with or without helicobacter pylori infectionen_US
dc.typearticleen_US
dc.relation.journalActa Cirurgica Brasileiraen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0001-9110-8364en_US
dc.identifier.volume34en_US
dc.identifier.issue3en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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