Plasma nesfatin-1 levels and its relationship with anxiety levels in obesity diagnosed population: A controlled study
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Erişim
info:eu-repo/semantics/openAccessTarih
2019Yazar
Baykan, HayriyeBaykan, Özgür
Durmaz, Onur
Gülşah, Oğuz Elif
Kara, Hayrettin
Görgülü, Serap Akdeniz
Yaman, Ali
Karlıdere, Tunay
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Objective: Nesfatin-1 is a satiety neuropeptide involved in the regulation of metabolic pathways and food intake. Some studies have shown nesfatin-1 to be also associated with stress responses and stress-related behaviors. In the present study, we evaluated nesfatin-1 levels in obese individuals and investigated whether nesfatin-1 levels could be associated with anxiety levels in obese populations.
Methods: Fifty-eight obese (29 anxious and 29 non-anxious) patients and 25 healthy control subjects between 18 and 65 years old were enrolled in the study. Plasma nesfatin-1 levels were measured with a commercial enzyme-linked immunosorbent assay, and anxiety levels were measured using the Hospital Anxiety and Depression Scale.
Results: Plasma nesfatin-1 levels were significantly lower in both obese and anxious subjects and obese and non-anxious subjects than in the control group. No significant differences were found between the obese+anxious group and the obese+nonanxious group.
Conclusion: Our results suggest that plasma nesfatin-1 levels are decreased and not associated with anxiety levels in obese populations