Yazar "Hacıoğlu, Nelin" için listeleme
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Adamts14 Promotorunun Klonlanması ve Karakterizasyonu
Albazi, Ghufran Haqi Ismael (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2023)ADAMTS genlerinin, tümörlerin ortaya çıkması, gelişmesi ve metastazında önemli bir rol oynadığı ortaya konmuştur. Bu gen ailesinin üyelerinden biri olan ADAMTS14 geni kollajen içerikli ADAMTS grubunu oluşturmaktadır. ... -
Antikanser etkili bazı nitroredüktaz ilaç öncü bileşimlerinin moleküler mekanizmasının belirlenmesi
Hacıoğlu, Nelin (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Nitrolu bileşikler kanserli hücreler üzerinde yüksek hücre ölümü oluşturan ve nitroredüktaz adı verilen enzimler ile etkin hale gelebilen bileşiklerdir. Nitroredüktaz enzimi aracılığıyla ilaç öncüllerinden elde edilen etkin ... -
Cloning of the Ssap-NtrB prokaryotic gene into the eukaryotic expression vector pcDNA3.1 / V5 / His B vector
Hacıoğlu, Nelin; Köçkar, Feray (Balıkesir Üniversitesi, 2020)Suicide gene therapy has recently emerged as a method used in cancer treatments. These therapies utilized enzymes that are expressed in the cell. In this study, Staphylococcus saprophyticus supsp. saprophyticus Nitroreductase ... -
Investigation of the effects of post-operative intraperitoneal, oral, and rectal phenytoin administration on colorectal anastomosis in rats
Duran, Ali; Çay, Ferhat; Hacıoğlu, Nelin; Tokay, Esra; Köçkar, Feray; Altun, Eren; Başbuğ, Murat; Şahin, Azad Gazi (Turkish Assoc Trauma Emergency Surgery, 2022)BACKGROUND: Anastomotic leakage is the most feared complication after colonic anastomosis. The purpose of the study is to determine the effects of phenytoin applied by different application routes, on the healing process ... -
Is phenytoin a safe agent for staple line recovery after gastric sleeve surgery in rats?
Çay, Ferhat; Duran, Ali; Tokay, Esra; Hacıoğlu, Nelin; Köçkar, Feray; Altun, Eren; Kanat, Burhan Hakan (Turkish Association of Trauma and Emergency Surgery, 2023)BACKGROUND: The most challenging and mortal complication of gastric sleeve surgery (SG) is staple line leakage. Although many agents have been used for increasing tissue healing on the stapler line, there is still no ... -
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
Güngör, Tuğba; Önder, Ferah Cömert; Tokay, Esra; Gülhan, Ünzile Güven; Hacıoğlu, Nelin; Tok, Tuğba Taşkın; Çelik, Ayhan; Köçkar, Feray; Ay, Mehmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ... -
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation
Güngör, Tuğba; Tokay, Esra; Gülhan, Ünzile Güven; Hacıoğlu, Nelin; Çelik, Ayhan; Köçkar, Feray; Ay, Mehmet (Academic Press Inc Elsevier Science, 2020)In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well ... -
Prodrugs for nitroreductase based cancer therapy-5: Development of trinitroaniline Prodrugs/Ssap-NtrB combinations for liver cancer using intracellular and extracellular conditions
Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Gülhan, Ünzile Güven; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Wiley-V C H Verlag GMBH, 2021)In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ... -
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
Tokay, Esra; Güngör, Tuğba; Hacıoğlu, Nelin; Önder, Ferah Cömert; Gülhan, Ünzile Güven; Tok, Tuğba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Önder, Ferah Cömert; Ay, Mehmet; Köçkar, Feray (Springer Wien, 2020)Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ...
