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dc.contributor.authorBaykalır, Burcu Gül
dc.contributor.authorArslan, Aslıhan Sur
dc.contributor.authorMutlu, Seda İflazoğlu
dc.contributor.authorAk, Tuba Parlak
dc.contributor.authorSeven, İsmail
dc.contributor.authorSeven, Pınar Tatlı
dc.contributor.authorYaman, Mine
dc.contributor.authorGül, Hüseyin Fatih
dc.date.accessioned2021-08-13T11:00:13Z
dc.date.available2021-08-13T11:00:13Z
dc.date.issued2020en_US
dc.identifier.issn0300-9831
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000653
dc.identifier.urihttps://hdl.handle.net/20.500.12462/11583
dc.descriptionArslan, Aslıhan Sur (Balikesir Author)en_US
dc.description.abstractAbstract: The aim of this study was to investigate the possible protective effects of chrysin on oxidative status and histological alterations against carbon tetrachloride (CCl4)-induced liver and kidney tissue in rats. The animals were randomly divided into four groups; the control, chrysin (100 mg/kg), CCl4 (0.5 ml/kg) and chrysin + CCl4 groups. Liver and kidney injuries were assessed by biochemical and histopathological examinations. The levels of malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) activity were measured in tissues. Serum tumor necrosis factor-α (TNF-α), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels were also measured in blood samples. MDA, serum TNF-α, AST, ALT, urea, and creatinine levels (p < 0.05) were significantly higher, and SOD activity and GSH level were significantly (p < 0.05) lower in the CCl4 group than in the control group. Treatment with chrysin in the chrysin + CCl4 group decreased MDA, AST, ALT, creatinine, and TNF-α levels (p < 0.05), and increased SOD activity, GSH levels (p < 0.05), and serum TNF-α levels (p < 0.05). In addition, body weight change (BWC) (p < 0.05) and feed intake (FI) were significantly lower (p < 0.001) in the CCl4 group than in the control group. Moreover, treatment with chrysin increased BWC and FI in the chrysin + CCl4 group compared with that in the CCl4 group. These findings also confirmed by histopathological examination. The chrysin treatment ameliorated the CCl4-induced biochemical and pathological alterations. These results demonstrated that chrysin provided amelioration on the rat liver and kidney tissues CCl4-induced injury by increasing the antioxidant activity.en_US
dc.language.isoengen_US
dc.publisherHogrefe Verlag GmbH & Co. KGen_US
dc.relation.isversionof10.1024/0300-9831/a000653en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectChrysinen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.titleThe protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage in ratsen_US
dc.typearticleen_US
dc.relation.journalInternational Journal for Vitamin and Nutrition Researchen_US
dc.contributor.departmentKepsut Meslek Yüksekokuluen_US
dc.identifier.startpage1en_US
dc.identifier.endpage12en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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